{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T22:08:58Z","timestamp":1776982138008,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied 2,528 patients with upfront autologous haematopoietic cell transplantation (AHCT) for multiple myeloma (MM) from 2008\u20132017 to develop a prognostic model to predict outcomes. High\u2010risk cytogenetics included t(4;14), t(14;16), t(14;20), del13q on karyotype, del17p, +1q or 1pdel. A Cox model identified factors prognostic of progression\/relapse in a training subset (<jats:italic>n<\/jats:italic> =\u00a01,246). A weighted score using these factors was assigned to a validation cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0774). Presence of high\u2010risk cytogenetics [hazard ratio, (HR) 1\u00b768 (1\u00b73\u20132\u00b717)] and pre\u2010AHCT bone marrow plasma cells (BMPCs) \u226510% [1\u00b768 (1\u00b733\u20132\u00b712)] were assigned 4 points each; albumin at diagnosis &lt;3\u00b75\u00a0g\/dl [1\u00b731 (1\u00b707\u20131\u00b761)] 2; standard risk cytogenetics 1, and no cytogenetics abnormality, BMPCs &lt;10% at AHCT and albumin \u22653\u00b75\u00a0g\/dl at diagnosis 0 points each. A three\u2010category system with low risk (0\u20133), intermediate risk (4\u20138) and high risk (9\u201310) showed 3\u2010year progression\u2010free survival in the low vs. intermediate vs. high risk of 58% (95% CI: 52\u201363) vs. 49% (95% CI: 43\u201356) vs. 31% (95% CI: 12\u201351), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 respectively, and 3\u2010year OS in low vs. intermediate vs. high risk of 88% (95% CI: 84\u201391) vs. 81% (95% CI: 76\u201386) vs. 64% (95% CI: 39\u201380); <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001. Our prognostic scoring system can identify MM patients at risk for early relapse after AHCT.<\/jats:p>","DOI":"10.1111\/bjh.16987","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T15:56:06Z","timestamp":1603468566000},"page":"442-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Novel prognostic scoring system for autologous hematopoietic cell transplantation in multiple myeloma"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-9742","authenticated-orcid":false,"given":"Binod","family":"Dhakal","sequence":"first","affiliation":[{"name":"BMT and Cellular Therapy Division of Hematology\/Oncology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"D\u2019Souza","sequence":"additional","affiliation":[{"name":"CIBMTR<sup><i>\u00ae<\/i><\/sup> (Center for International Blood and Marrow Transplant Research) Department of Medicine Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Callander","sequence":"additional","affiliation":[{"name":"University of Wisconsin Carbone Cancer Center Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-8696","authenticated-orcid":false,"given":"Saurabh","family":"Chhabra","sequence":"additional","affiliation":[{"name":"CIBMTR<sup><i>\u00ae<\/i><\/sup> (Center for International Blood and Marrow Transplant Research) Department of Medicine Medical College of Wisconsin Milwaukee WI USA"},{"name":"Division of Hematology\/Oncology Department of Medicine Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphael","family":"Fraser","sequence":"additional","affiliation":[{"name":"CIBMTR<sup><i>\u00ae<\/i><\/sup> (Center for International Blood and Marrow Transplant Research) Department of Medicine Medical College of Wisconsin Milwaukee WI USA"},{"name":"Division of Biostatistics Institute for Health and Equity Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Davila","sequence":"additional","affiliation":[{"name":"CIBMTR<sup><i>\u00ae<\/i><\/sup> (Center for International Blood and Marrow Transplant Research) Department of Medicine Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Anderson","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amer","family":"Assal","sequence":"additional","affiliation":[{"name":"Department of Medicine Bone Marrow Transplant and Cell Therapy Program Columbia University Irving Medical Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif M.","family":"Badawy","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology and Stem Cell Transplant Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago Chicago IL USA"},{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesus","family":"Berdeja","sequence":"additional","affiliation":[{"name":"Sarah Cannon Research Institute Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Cerny","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology Department of Medicine University of Massachusetts Medical Center Worcester MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6255-5824","authenticated-orcid":false,"given":"Raymond","family":"Comenzo","sequence":"additional","affiliation":[{"name":"Tufts Medical Center Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-3003","authenticated-orcid":false,"given":"Rajshekhar","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Taussig Cancer Center Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Peter Gale","sequence":"additional","affiliation":[{"name":"Haematology Research Centre Department of Immunology and Inflammation Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rammurti","family":"Kamble","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Center for Cell and Gene Therapy Baylor College of Medicine Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed A.","family":"Kharfan\u2010Dabaja","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Blood and Marrow Transplantation Program Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxwell","family":"Krem","sequence":"additional","affiliation":[{"name":"University of Louisville Hospital\/James Brown Cancer Center Louisville KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhartha","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Division of Hematological Malignancy and Cellular Therapeutics University of Kansas Health System Kansas City KS USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murali","family":"Janakiram","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center Bronx NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ankit","family":"Kansagra","sequence":"additional","affiliation":[{"name":"UT Southwestern Medical Center \u2010 BMT Program Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Munker","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky Lexington KY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemant","family":"Murthy","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology, Blood and Marrow Transplantation Program Mayo Clinic Jacksonville FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9949-3615","authenticated-orcid":false,"given":"Sagar","family":"Patel","sequence":"additional","affiliation":[{"name":"Blood and Marrow Transplant Program University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5392-9284","authenticated-orcid":false,"given":"Shaji","family":"Kumar","sequence":"additional","affiliation":[{"name":"Taussig Cancer Center Cleveland Clinic Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Hematology<i>\u2010Oncology<\/i> <i>University of California San Francisco<\/i> San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muzaffar","family":"Qazilbash","sequence":"additional","affiliation":[{"name":"M.D. Anderson Cancer Center Houston TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parameswaran","family":"Hari","sequence":"additional","affiliation":[{"name":"CIBMTR<sup><i>\u00ae<\/i><\/sup> (Center for International Blood and Marrow Transplant Research) Department of Medicine Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.46"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12360"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4600"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402888"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2016.07.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30206-6"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.12.141"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0329"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.016436"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.247"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01635.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24236"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-05-644039"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-06-653261"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-631200"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.08.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.237"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.147"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2008.180"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.331"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00776"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.08.013"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.185"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611750"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31594-X"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2016.1201572"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-858613"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.3160"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.10.023"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31240-1"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.92"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.07.013"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.174"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16987","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.16987","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.16987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T10:45:44Z","timestamp":1693392344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.16987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/bjh.16987"],"URL":"https:\/\/doi.org\/10.1111\/bjh.16987","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"assertion":[{"value":"2020-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}