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However, fatalities occurring within the first 30\u00a0days of induction treatment, in particular intracranial haemorrhage (ICH), remain the main causes of death. We studied the clinico\u2010biological characteristics of 13 patients with APL who experienced ICH. Compared to 85 patients without this complication, patients with ICH were older and more frequently had high\u2010risk APL. Moreover, positivity for the \u2018swirl\u2019 sign at neuroradiological imaging and hydrocephalus were predictors of a fatal outcome, together with lower fibrinogen, prolonged international normalized ratio (INR) and higher lactate dehydrogenase levels.<\/jats:p>","DOI":"10.1111\/bjh.17018","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T05:10:49Z","timestamp":1597036249000},"page":"129-132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico\u2010biological parameters"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-5544","authenticated-orcid":false,"given":"Carmelo","family":"Gurnari","sequence":"first","affiliation":[{"name":"Department of Biomedicine and Prevention University of Rome Tor Vergata Rome 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