{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:16:58Z","timestamp":1763018218846,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T00:00:00Z","timestamp":1597190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Haematology patients receiving chemo\u2010 or immunotherapy are considered to be at greater risk of COVID\u201019\u2010related morbidity and mortality. We aimed to identify risk factors for COVID\u201019 severity and assess outcomes in patients where COVID\u201019 complicated the treatment of their haematological disorder. A retrospective cohort study was conducted in 55 patients with haematological disorders and COVID\u201019, including 52 with malignancy, two with bone marrow failure and one immune\u2010mediated thrombotic thrombocytopenic purpura (TTP). COVID\u201019 diagnosis coincided with a new diagnosis of a haematological malignancy in four patients. Among patients, 82% were on systemic anti\u2010cancer therapy (SACT) at the time of COVID\u201019 diagnosis. Of hospitalised patients, 37% (19\/51) died while all four outpatients recovered. Risk factors for severe disease or mortality were similar to those in other published cohorts. Raised C\u2010reactive protein at diagnosis predicted an aggressive clinical course. The majority of patients recovered from COVID\u201019, despite receiving recent SACT. This suggests that SACT, where urgent, should be administered despite intercurrent COVID\u201019 infection, which should be managed according to standard pathways. Delay or modification of therapy should be considered on an individual basis. Long\u2010term follow\u2010up studies in larger patient cohorts are required to assess the efficacy of treatment strategies employed during the pandemic.<\/jats:p>","DOI":"10.1111\/bjh.17027","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T18:34:36Z","timestamp":1595010876000},"page":"194-206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Clinical outcomes and risk factors for severe COVID\u201019 in patients with haematological disorders receiving chemo\u2010 or immunotherapy"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-2295","authenticated-orcid":false,"given":"Thomas A.","family":"Fox","sequence":"first","affiliation":[{"name":"Department of Haematology University College London NHS Foundation Trust London UK"},{"name":"UCL Institute of Immunity and Transplantation UCL London 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