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Antiviral therapy for MC, based on interferon and ribavirin, has been shown to be able to eliminate the viral replication as well as the B\u2010cell monoclonal alterations. Many studies have reported the efficacy of direct\u2010acting antivirals (DAAs) in the treatment of HCV+ MC. However, some authors noticed the persistence of haematological diseases despite HCV eradication. To verify the effects of DAAs on B\u2010cell proliferation, we evaluated 67 patients with HCV+ MC. Six patients had an overt NHL and 30% had monoclonal B\u2010lymphocytosis. In 20% of the patients, the mutation L265P of the myeloid differentiation factor 88 (<jats:italic>MYD88<\/jats:italic>) gene was detected in peripheral blood. All patients had negative HCV viraemia at week 12; one had a breakthrough, while two cases relapsed. A complete clinical response of vasculitis was seen in 60% of the patients. Among the six patients with NHL, one showed a complete response, whereas in the others there were no changes in the number and size of the nodes. Among the patients carrying a clonal population in peripheral blood, only 22% became negative. These data indicate that DAAs are not able to eliminate the clonal alterations induced by HCV in a large proportion of cases.<\/jats:p>","DOI":"10.1111\/bjh.17036","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T21:21:48Z","timestamp":1597353708000},"page":"775-783","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Direct\u2010acting antiviral agents for hepatitis C virus\u2010mixed cryoglobulinaemia: dissociated virological and haematological responses"],"prefix":"10.1111","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-8398","authenticated-orcid":false,"given":"Gabriele","family":"Pozzato","sequence":"first","affiliation":[{"name":"Department of Clinical and Surgical Sciences University of Trieste Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Mazzaro","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Onco\u2010Haematology Unit CRO Aviano National Cancer Institute IRCCS Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Artemova","sequence":"additional","affiliation":[{"name":"Department of Fundamental Medicine Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dzhamal","family":"Abdurakhmanov","sequence":"additional","affiliation":[{"name":"I.M. 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