{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T02:04:35Z","timestamp":1791338675820,"version":"4.3.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Burkitt lymphoma (BL) accounts for almost two\u2010thirds of all B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL) in children and adolescents and is characterised by a <jats:italic>MYC<\/jats:italic> translocation and rapid cell turnover. Intensive chemotherapeutic regimens have been developed in recent decades, including the lymphomes malins B (LMB) protocol, which have resulted in a survival rate in excess of 90%. Recent clinical trials have focused on immunochemotherapy, with the addition of rituximab to chemotherapeutic backbones, showing encouraging results. Despite these advances, relapse and refractory disease occurs in up to 10% of patients and salvage options for these carry a dismal prognosis. Efforts to better understand the molecular and functional characteristics driving relapse and refractory disease may help improve this prognosis. This study has established a paediatric BL patient\u2010derived xenograft (PDX) resource which captures and maintains tumour heterogeneity, may be used to better characterise tumours and identify cell populations responsible for therapy resistance.<\/jats:p>","DOI":"10.1111\/bjh.17043","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T14:14:25Z","timestamp":1599142465000},"page":"354-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Paediatric Burkitt lymphoma patient\u2010derived xenografts capture disease characteristics over time and are a model for therapy"],"prefix":"10.1111","volume":"192","author":[{"given":"Sorcha","family":"Forde","sequence":"first","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie D.","family":"Matthews","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Jahangiri","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"},{"name":"Department of Life Sciences Birmingham City University Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam C.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Prokoph","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim I.M.","family":"Malcolm","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier T.","family":"Giger","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie","family":"Bell","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Blair","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aengus","family":"O'Marcaigh","sequence":"additional","affiliation":[{"name":"Children's Health Ireland at Crumlin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Smith","sequence":"additional","affiliation":[{"name":"Children's Health Ireland at Crumlin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Kenner","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical University of Vienna Vienna Austria"},{"name":"Unit of Laboratory Animal Pathology University of Veterinary Medicine Vienna Vienna Austria"},{"name":"Christian Doppler Laboratory for Applied Metabolomics Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Bomken","sequence":"additional","affiliation":[{"name":"Wolfson Childhood Cancer Research Centre Translational and Clinical Research Institute Newcastle University Newcastle upon Tyne UK"},{"name":"The Great North Children's Hospital The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"},{"name":"Northern Institute for Cancer Research Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2671-9972","authenticated-orcid":false,"given":"Gladstone A. 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