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Despite numerous studies examining the aetiology of spontaneous abortion, there is limited understanding of the disordered iron transportation between mother and fetus through the placenta. Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis. However, its diagnostic significance in different disease conditions associated with iron remains poorly understood. In the current study, we discovered disordered maternal iron homeostasis in women who had spontaneous abortions during early pregnancy, as characterized by increased serum iron and hepcidin levels, and conversely, reduced serum ERFE levels, compared to healthy control individuals and women with normal pregnancy. Comprehensive statistical analyses revealed the correlation between different variables and pregnancy status, signifying the pronounced diagnostic value of an increased ratio of serum hepcidin and ERFE (HE ratio) in recognizing adverse pregnancy status. In contrast to previous non\u2010selective discrete surrogates, such as iron, hepcidin and ferritin, the HE ratio may otherwise stand for a novel and more representative hallmark for early spontaneous abortion.<\/jats:p>","DOI":"10.1111\/bjh.17049","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T17:20:22Z","timestamp":1598894422000},"page":"643-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans"],"prefix":"10.1111","volume":"192","author":[{"given":"Shuting","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco\u2010Environmental Sciences Chinese Academy of Sciences Beijing China"},{"name":"College of Environment and Resource Research Center of 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