{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:40:11Z","timestamp":1790707211652,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Burkitt lymphoma (BL) is an aggressive B\u2010cell\u2010malignancy derived from germinal\u2010centre B\u2010cells. Curative therapy traditionally requires intensive immunochemotherapy. Recently, immuno\u2010oncological approaches, modulating the T\u2010cell tumour response, were approved for the treatment of a variety of malignancies. The architecture of the tumour\u2010infiltrating T\u2010cell receptor (TCR) repertoire in BL remains insufficiently characterized. We therefore performed a large\u2010scale, next\u2010generation sequencing study of the complimentary\u2010determining region (CDR)\u20103 region of the TCR\u03b2 chain repertoire in a large cohort of all epidemiological subtypes of BL (<jats:italic>n<\/jats:italic>\u00a0=\u00a082) and diffuse large B\u2010cell lymphoma (DLBCL; <jats:italic>n<\/jats:italic>\u00a0=\u00a034). Molecular data were subsequently assessed for correlation with clinical outcome. Our investigations revealed an age\u2010dependent immunoprofile in BL as in DLBCL. Moreover, we found several public clonotypes in numerous patients suggestive of shared tumour neoantigen selection exclusive to BL and distinct from DLBCL regardless of Epstein\u2013Barr virus and\/or human immunodeficiency virus status. Compared with baseline, longitudinal analysis unveiled significant repertoire restrictions upon relapse (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70437) while productive TCR repertoire clonality proved to be a useful indicator of both overall and progression\u2010free\u2010survival [OS: <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001; hazard ratio (HR): 6\u00b7220; confidence interval (CI): 2\u00b7263\u201311\u00b778; PFS: <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70025; HR: 3\u00b7086; CI: 1\u00b7555\u20137\u00b7030]. Multivariate analysis confirmed its independence from established prognosticators, including age at diagnosis and comorbidities. Our findings establish the clinical relevance of the architecture and clonality of the TCR repertoire and its age\u2010determined dynamics in BL.<\/jats:p>","DOI":"10.1111\/bjh.17083","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T11:57:15Z","timestamp":1600430235000},"page":"138-149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Exhaustion of tumour\u2010infiltrating T\u2010cell\u00a0receptor repertoire diversity is an age\u2010dependent indicator of immunological fitness independently predictive of clinical outcome in Burkitt lymphoma"],"prefix":"10.1111","volume":"193","author":[{"given":"Johannes","family":"Rieken","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology University Hospital of Schleswig\u2010Holstein Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Bernard","sequence":"additional","affiliation":[{"name":"H\u00e4matopathologie L\u00fcbeck Reference Centre for Lymph Node Pathology and Haematopathology L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5767-7125","authenticated-orcid":false,"given":"Hanno M.","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology University Hospital of Schleswig\u2010Holstein Luebeck Germany"},{"name":"Department of Haematology and Oncology Federal Armed Hospital Ulm Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Peter","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory of the Stefan\u2010Morsch\u2010Foundation Birkenfeld 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