{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:01:28Z","timestamp":1771462888058,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The Revised International Staging System (R\u2010ISS) stratifies patients affected by Multiple Myeloma (MM) into three distinct risk groups: R\u2010ISS I [ISS Stage I, Standard\u2010Risk cytogenetics and normal Lactase DeHydrogenase (LDH)], R\u2010ISS III (ISS stage III and either high\u2010risk cytogenetics or high LDH) and R\u2010ISS II (any other characteristics). With the aim to verify whether the three R\u2010ISS groups could be divided into subgroups with different prognostic factors based on the detection of Circulating Plasma Cells (CPCs) at diagnosis, in this retrospective analysis, we evaluated 161 patients with MM treated at our centre between 2005 and 2017. In all, 57 patients (33\u00b79%) were staged as R\u2010ISS III, 98 (58\u00b73%) as R\u2010ISS II and six (3\u00b76%) as R\u2010ISS I. CPCs were detected in 125 patients (74\u00b74%), while in 43 patients (25\u00b76%) no CPCs were seen. Our analysis revealed that Overall Survival (OS) and progression\u2010free survival (PFS) rates in R\u2010ISS II patients were higher in the subgroup without CPCs compared to the subgroup with \u22651\u00a0CPCs (OS: 44\u00b77% vs. 16\u00b73%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70089; PFS: 27\u00b78% vs. 8\u00b71%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70118). Our present findings suggest that the detection of CPCs at diagnosis may be used as a further prognostic biomarker to improve the risk stratification of patients with MM staged as R\u2010ISS II.<\/jats:p>","DOI":"10.1111\/bjh.17118","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T07:54:05Z","timestamp":1617263645000},"page":"542-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The detection of circulating plasma cells may improve the Revised International Staging System (R\u2010ISS) risk stratification of patients with newly diagnosed multiple myeloma"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-264X","authenticated-orcid":false,"given":"Piero","family":"Galieni","sequence":"first","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fosco","family":"Travaglini","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Vagnoni","sequence":"additional","affiliation":[{"name":"UOC Clinical Pathology ASUR Marche Civitanova Marche Hospital Costamartina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriana","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Caraffa","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catia","family":"Bigazzi","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadia","family":"Falcioni","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Picardi","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Mazzotta","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Troiani","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Dalsass","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5391-1671","authenticated-orcid":false,"given":"Francesca","family":"Mestichelli","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Camaioni","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Maravalle","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-3564","authenticated-orcid":false,"given":"Stefano","family":"Angelini","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4313-5779","authenticated-orcid":false,"given":"Valerio","family":"Pezzoni","sequence":"additional","affiliation":[{"name":"Department of Haematology and Stem Cell Transplantation Unit C. e G. Mazzoni Hospital Ascoli Piceno Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1881"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt297"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0023"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60221-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2008.1.297"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.34.15_suppl.8001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2015.11.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016003905"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70143-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/bcj.2015.91"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.242"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.61"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-631200"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.2267"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1858"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.98"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.237"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.205"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.166629"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.02.017"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13484"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25117"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.01.001"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0181447"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.145078"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25709"},{"key":"e_1_2_8_29_1","unstructured":"BertaminiL CapraA ZaccariaGM D\u2019AgostinoM OlivaS ZambelloR et al.High levels of circulating plasma cells predict low rate of sustained minimal residual disease negativity in transplant eligible multiple myeloma patients treated with novel agents. Ehaweb.org. The European Hematology Association. Cited 2020 August 24. Available from:https:\/\/library.ehaweb.org"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17118","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17118","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T09:09:11Z","timestamp":1693559351000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/bjh.17118"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17118","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"2020-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}