{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:17:59Z","timestamp":1780676279243,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Previously, we showed that nearly 70% of children followed in our sickle cell disease (SCD) clinic were vitamin D\u2010 deficient and had low vitamin intake with poor use of supplements. We compared the change in serum 25\u2010hydroxyvitamin D [25(OH)D], safety and clinical impact of two vitamin D supplementation regimens in children with SCD. Children (5\u201317\u00a0years, all genotypes) were randomized to a single bolus of vitamin D<jats:sub>3<\/jats:sub> (300\u00a0000\u00a0IU; <jats:italic>n<\/jats:italic>\u00a0=\u00a018) or placebo (<jats:italic>n<\/jats:italic>\u00a0=\u00a020). All children received a prescription for daily 1\u00a0000\u00a0IU vitamin D<jats:sub>3<\/jats:sub>. Serum 25(OH)D and calcium, urinary calcium\/creatinine ratio, musculoskeletal pain, quality of life, haematology and bone markers were assessed at baseline and three\u00a0months post intervention. Bolus administration led to a greater rise in 25(OH)D levels from baseline compared to placebo (20\u00a0\u00b1\u00a016\u00a0nmol\/l vs. 2\u00a0\u00b1\u00a019\u00a0nmol\/l; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003) and correction of vitamin D deficiency. No hypercalcaemia nor hypercalciuria occurred during the study, but more children in the bolus group experienced gastrointestinal symptoms within the first month (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704). There were no differences between groups for other outcomes. The use of a high\u2010dose vitamin D bolus combined with daily 1\u00a0000\u00a0IU vitamin D<jats:sub>3<\/jats:sub> was more efficient in raising 25(OH)D levels than daily supplementation alone in children with SCD.<\/jats:p>","DOI":"10.1111\/bjh.17119","type":"journal-article","created":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T21:08:33Z","timestamp":1605042513000},"page":"385-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of two vitamin D supplementation strategies in children with sickle cell disease: a randomized controlled trial"],"prefix":"10.1111","volume":"192","author":[{"given":"Pascale","family":"Gr\u00e9goire\u2010Pelchat","sequence":"first","affiliation":[{"name":"Department of Nutrition Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"Research Center Centre Hospitalier Universitaire Sainte\u2010Justine Montreal Quebec 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