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We analysed expression profile data of KLFs and identified KLF6 as a new potential regulator of erythropoiesis. Knocking down the expression of KLF6 significantly raised \u03b3\u2010globin mRNA and protein levels in the erythroid cell line HUDEP\u20102 and haematopoietic progenitor (CD34<jats:sup>+<\/jats:sup>) cells. We found that overexpression of microRNA (miR)\u20102355\u20105p in HUDEP\u20102 and CD34<jats:sup>+<\/jats:sup> cells correlated with increased \u03b3\u2010globin synthesis by suppressing expression of KLF6. Our discovery that the interaction between miR\u20102355\u20105p and KLF6 affects the expression of \u03b3\u2010globin may provide more information for the clinical management of \u03b2\u2010thalassaemia patients.<\/jats:p>","DOI":"10.1111\/bjh.17134","type":"journal-article","created":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T09:32:51Z","timestamp":1608888771000},"page":"401-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["MicroRNA\u20102355\u20105p regulates \u03b3\u2010globin expression in human erythroid cells by inhibiting KLF6"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-5578","authenticated-orcid":false,"given":"Yi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Medical Genetics School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong 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