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However, data in follicular lymphoma (FL) are scarce. We studied 311 FL patients diagnosed at a single institution, for whom information on serum immunofixation electrophoresis (sIFE) at diagnosis was available. Baseline characteristics and outcomes were compared between patients with a positive (+sIFE) and a negative sIFE (\u2212sIFE). sIFE was positive in 82 patients (26%). Baseline features were comparable between both groups, except for an older age and higher proportion of elevated \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin levels in the +sIFE group. With a median follow\u2010up of 4.6\u00a0years, a +sIFE was associated with a higher risk of early relapse (POD24, 27% vs. 15%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702), shorter progression\u2010free survival (PFS; 42% vs. 52% at 5\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008), and shorter overall survival (OS; 59% vs. 77% at 10\u00a0years, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7046). In patients &gt;60\u00a0years, a +sIFE was an independent predictor of OS [hazard ratio (HR)\u00a0=\u00a02\u00b74, 95% confidence interval (CI): 1\u00b72\u20135\u00b70; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702]. Approximately one quarter of patients with FL has a +sIFE at diagnosis, which is a predictor of poor outcome. These findings encourage further investigation of its relationship with B\u2010cell biology and the tumour microenvironment.<\/jats:p>","DOI":"10.1111\/bjh.17138","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T06:48:33Z","timestamp":1605595713000},"page":"299-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Baseline correlations and prognostic impact of serum monoclonal proteins in follicular lymphoma"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-4971","authenticated-orcid":false,"given":"Pablo","family":"Mozas","sequence":"first","affiliation":[{"name":"Department of Haematology Hospital Cl\u00ednic de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rivero","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Cl\u00ednic de Barcelona 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