{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T20:49:33Z","timestamp":1776977373509,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T00:00:00Z","timestamp":1607817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A translocation involving the cyclin\u2010dependent kinase 6 (<jats:italic>CDK6<\/jats:italic>) gene [t(<jats:italic>CDK6<\/jats:italic>)] is a rare but recurrent abnormality in B\u2010cell neoplasms. To further characterise this aberration, we studied 57 cases; the largest series reported to date. Fluorescence <jats:italic>in situ<\/jats:italic> hybridisation analysis confirmed the involvement of <jats:italic>CDK6<\/jats:italic> in all cases, including t(2;7)(p11;q21) immunoglobulin kappa locus (<jats:italic>IGK<\/jats:italic>)\/<jats:italic>CDK6<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a051), t(7;14)(q21;q32) <jats:italic>CDK6<\/jats:italic>\/immunoglobulin heavy locus (<jats:italic>IGH<\/jats:italic>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and the previously undescribed t(7;14)(q21;q11) <jats:italic>CDK6<\/jats:italic>\/T\u2010cell receptor alpha locus (<jats:italic>TRA<\/jats:italic>)\/T\u2010cell receptor delta locus (<jats:italic>TRD<\/jats:italic>) (<jats:italic>n<\/jats:italic>\u00a0=\u00a04). In total, 10 patients were diagnosed with chronic lymphocytic leukaemia, monoclonal B\u2010cell lymphocytosis or small lymphocytic lymphoma, and 47 had small B\u2010cell lymphoma (SmBL) including 36 cases of marginal zone lymphoma (MZL; 34 splenic MZLs, one nodal MZL and one bronchus\u2010associated lymphoid tissue lymphoma). In all, 18 of the 26 cytologically reviewed cases of MZL (69%) had an atypical aspect with prolymphocytic cells. Among the 47 patients with MZL\/SmBL, CD5 expression was found in 26 (55%) and the tumour protein p53 (<jats:italic>TP53<\/jats:italic>) deletion in 22 (47%). The <jats:italic>TP53<\/jats:italic> gene was mutated in 10\/30 (33%); the 7q deletion was detected in only one case, and no Notch receptor 2 (<jats:italic>NOTCH2<\/jats:italic>) mutations were found. Immunoglobulin heavy\u2010chain variable\u2010region (<jats:italic>IGHV<\/jats:italic>) locus sequencing revealed that none harboured an <jats:italic>IGHV1\u201002*04<\/jats:italic> gene. Overall survival was 82% at 10\u00a0years and not influenced by <jats:italic>TP53<\/jats:italic> aberration. Our present findings suggest that most t(<jats:italic>CDK6<\/jats:italic>)+ neoplasms correspond to a particular subgroup of indolent marginal zone B\u2010cell lymphomas with distinctive features.<\/jats:p>","DOI":"10.1111\/bjh.17141","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T21:24:06Z","timestamp":1607894646000},"page":"72-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical and biological features of B\u2010cell neoplasms with <i>CDK6<\/i> translocations: an association with a subgroup of splenic marginal zone lymphomas displaying frequent CD5 expression, prolymphocytic cells, and <i>TP53<\/i> abnormalities"],"prefix":"10.1111","volume":"193","author":[{"given":"Baptiste","family":"Gailllard","sequence":"first","affiliation":[{"name":"Laboratoire d'H\u00e9matologie H\u00f4pital Robert Debr\u00e9 Reims 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