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The vast majority of patients diagnosed with this rare, often diagnostically challenging, leukaemia can now expect a lifespan that is similar to the general population. This article covers some of the highlights from the last 6 decades that have led to our current understanding of this fascinating leukaemia \u2010 from elucidation of its B\u2010cell origin to discovery of the almost universal occurrence of the BRAF V600E mutation; from the initial successes reported with splenectomy to the more recent development of targeted therapies such as Vemurafenib and Moxetumomab Pasudotox. It also pays tribute to some of the outstanding research in this field focusing particularly on the significant contributions made by the clinical and scientific community in the UK.<\/jats:p>","DOI":"10.1111\/bjh.17158","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:19:19Z","timestamp":1693876759000},"page":"527-534","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hairy Cell Leukaemia: From Hairy Beginnings to a BRAF New World"],"prefix":"10.1111","volume":"191","author":[{"given":"Claire","family":"Dearden","sequence":"first","affiliation":[{"name":"The Royal Marsden Hospital and the Institute of Cancer Research Biomedical Research Centre  Sutton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Iyengar","sequence":"additional","affiliation":[{"name":"The Royal Marsden Hospital and the Institute of Cancer Research Biomedical Research Centre  Sutton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.6.567"},{"key":"e_1_2_7_3_1","unstructured":"SwerdlowSH CampoE HarrisNL JaffeES PileriSA SteinH et al. 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