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In the year 2020, &gt;90% of children and &gt;70% of young adults can expect to be cured with first\u2010line therapy and 20\u201350% of relapses can be salvaged depending on age and timing of relapse. The focus of treatment is gradually shifting from intensive therapy to the use of new agents to optimise efficacy, while minimising acute and long\u2010term toxicity. The UKALL trials have made important contributions to the refinement of treatment stratification and scheduling, which have delivered the excellent outcomes to date without new agents. This year UKALL, with other groups across Europe, will begin a new collaborative group working from a unified ALL protocol (ALLTogether) that will incorporate new agents including immune\u2010based approaches.<\/jats:p>","DOI":"10.1111\/bjh.17162","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:19:19Z","timestamp":1693876759000},"page":"562-567","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Improvements in outcome of childhood acute lymphoblastic leukaemia (ALL) in the UK \u2013 a success story of modern medicine through successive UKALL trials and international collaboration"],"prefix":"10.1111","volume":"191","author":[{"given":"Jack","family":"Bartram","sequence":"first","affiliation":[{"name":"Department of Haematology Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Veys","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplant Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Vora","sequence":"additional","affiliation":[{"name":"Department of Haematology Great Ormond Street Hospital for Children London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1834.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/tcbh\/hwn039"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM194806032382301"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.3676.1059"},{"key":"e_1_2_9_6_1","first-page":"777","article-title":"Studies in \u2018pernicious anemia\u2019 of pregnancy. 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