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In the UK, perhaps the most notable contributions relate to iron overload, some of which I will outline from personal experience. Diagnostically, this began with the identification of serum ferritin as a marker of iron overload and continued later with the application of MRI\u2010based imaging techniques for iron and its distribution. Therapeutically, the first trials of both parenteral and oral chelation, which have radically changed the outcomes of transfusional iron\u2010overloaded patients, took place in the UK and are now part of standard clinical practice. During this time, our scientific understanding of iron metabolism at a cellular and systemic level have advanced the diagnosis and treatment of inherited disorders of iron metabolism. There are potential novel applications related to our recent understanding of hepcidin metabolism and manipulation.<\/jats:p>","DOI":"10.1111\/bjh.17164","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T01:19:19Z","timestamp":1693876759000},"page":"587-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Iron Through the Prism of Haematology"],"prefix":"10.1111","volume":"191","author":[{"given":"John B.","family":"Porter","sequence":"first","affiliation":[{"name":"Department of Haematology University College London London 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