{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:30:36Z","timestamp":1792668636946,"version":"4.5.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A few prospective trials in HIV\u2010positive patients with Burkitt lymphoma (BL) or high\u2010grade B\u2010cell lymphoma (HGBL) have been reported. Investigated therapies have shown good efficacy but relevant safety problems, with high rates of interruptions, severe mucositis, septic complications, and fungal infections. Here, we report the results of a multicentre phase II trial addressing a new dose\u2010dense, short\u2010term therapy aimed at maintaining efficacy and improving tolerability. The experimental programme included a 36\u2010day polychemotherapy induction followed by high\u2010dose cytarabine\u2010based consolidation and response\u2010tailored BEAM (carmustine, etoposide, cyatarabine, and melphalan)\u2010 conditioned autologous stem cell transplantation (ASCT). This therapy would be considered active if \u226511 complete remissions (CR) after induction (primary endpoint) were recorded among 20 assessable patients. HIV\u2010positive adults (median age 42, range 26\u201358; 16 males) with untreated BL (<jats:italic>n<\/jats:italic>\u00a0=\u00a016), HGBL (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) or double\u2010hit lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a01) were enrolled. All patients had high\u2010risk features, with meningeal and bone marrow infiltration in five and nine patients respectively. The experimental programme was safe and active in a multicentre setting, with only two episodes of grade 4 non\u2010haematological toxicity (hepatotoxicity and mucositis), and no cases of systemic fungal infections; two patients died of toxicity (bacterial infections). Response after induction (median duration: 47\u00a0days; interquartile range 41\u201354), was complete in 13 patients and partial in five [overall response rate\u00a0=\u00a090%; 95% confidence interval (CI)\u00a0=\u00a077\u2013100]. All responders received consolidation, and five required autologous stem cell transplant. At a median follow\u2010up of 55 (41\u201389) months, 14 patients are relapse\u2010free and 15 are alive, with a five\u2010year progression\u2010free survival and an overall survival of 70% (95% CI\u00a0=\u00a060\u201380%) and 75% (95% CI\u00a0=\u00a066\u201384) respectively. No patient with cerebrospinal fluid (CSF)\/meningeal lymphoma experienced central nervous system recurrence. With respect to previously reported regimens, this programme was delivered in a shorter period, and achieved the main goal of maintaining efficacy and improving tolerability.<\/jats:p>","DOI":"10.1111\/bjh.17188","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T19:05:32Z","timestamp":1603307132000},"page":"119-128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A dose\u2010dense short\u2010term therapy for human immunodeficiency virus\/acquired immunodeficiency syndrome patients with high\u2010risk Burkitt lymphoma or high\u2010grade B\u2010cell lymphoma: safety and efficacy results of the \u201cCARMEN\u201d phase II trial"],"prefix":"10.1111","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-6124","authenticated-orcid":false,"given":"Andr\u00e9s J. M.","family":"Ferreri","sequence":"first","affiliation":[{"name":"Lymphoma Unit Department of Onco\u2010Hematology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arben","family":"Lleshi","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Immune\u2010related tumors IRCCS Centro di Riferimento Oncologico (CRO) Aviano (PN) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Verga","sequence":"additional","affiliation":[{"name":"Division of Hematology Azienda Ospedaliera San Gerardo Monza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Allione","sequence":"additional","affiliation":[{"name":"A.O. Citt\u00e0 della Salute e della Scienza \u2010 Le Molinette Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Facchetti","sequence":"additional","affiliation":[{"name":"Pathology Unit Ospedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurilio","family":"Ponzoni","sequence":"additional","affiliation":[{"name":"Pathology Unit IRCCS San Raffaele Scientific Institute Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Foppoli","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Department of Onco\u2010Hematology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daris","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology Azienda Ospedaliera San Paolo Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Rigacci","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedale Careggi Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Pecciarini","sequence":"additional","affiliation":[{"name":"Pathology Unit IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Donadoni","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Department of Onco\u2010Hematology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Fumagalli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Sassone","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Department of Onco\u2010Hematology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Calimeri","sequence":"additional","affiliation":[{"name":"Lymphoma Unit Department of Onco\u2010Hematology IRCCS San Raffaele Scientific Institute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Spina","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Immune\u2010related tumors IRCCS Centro di Riferimento Oncologico (CRO) Aviano (PN) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Re","sequence":"additional","affiliation":[{"name":"Division of Hematology Ospedali Civili di Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"95","article-title":"Characteristics and outcomes of HIV\u2010related Burkitt lymphoma (HIV\u2010BL) in the post\u2010rituximab era across 30 US cancer centers","volume":"105","author":"Alderuccio JP","year":"2020","journal-title":"Haematologica"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq677"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12284"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000147"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10365"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05141.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1308392"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051771"},{"key":"e_1_2_8_12_1","first-page":"335","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Kluin PM","year":"2017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.9355"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283301578"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-01-623900"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3167-7"},{"key":"e_1_2_8_17_1","first-page":"990","article-title":"Highly active antiretroviral therapy and outcome of AIDS\u2010related burkitt's lymphoma or leukemia. 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