{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:46:03Z","timestamp":1747183563928,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG\/GRK 2254\/A1\u2010HEIST"],"award-info":[{"award-number":["DFG\/GRK 2254\/A1\u2010HEIST"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Extra\u2010nodal marginal zone B\u2010cell lymphoma (MZBL) of mucosa\u2010associated lymphoid tissue is an indolent lymphoma mostly affecting the gastrointestinal tract. The lymphoma initially has small\u2010cell morphology (SC\u2010MZBL) and often arises in the background of <jats:italic>Helicobacter pylori<\/jats:italic>\u2010induced gastritis. In some cases, a clonal malignant progression to large\u2010cell morphology (LC\u2010MZBL) is observed. Here, we studied the DNA methylation profile of 30 gastric MZBLs along their progression. Genome\u2010wide DNA methylation profiling, identified 7698 significantly differentially methylated loci during gastric MZBL progression (\u03c3\/\u03c3<jats:sub>max<\/jats:sub> \u22650\u00b74, <jats:italic>q<\/jats:italic>\u00a0\u2264\u00a00\u00b7001). LC\u2010MZBL showed hypermethylation in comparison to SC\u2010MZBL with an enrichment of regions involved in transcriptional regulation. In conclusion, our present data show that the morphological distinction between SC\u2010 and LC\u2010MZBL is reflected by characteristic DNA methylation profiles.<\/jats:p>","DOI":"10.1111\/bjh.17193","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T06:01:54Z","timestamp":1613714514000},"page":"369-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genome\u2010wide DNA methylation analysis along the progression of gastric marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue (MALT) type"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-5813","authenticated-orcid":false,"given":"Rucha","family":"Dugge","sequence":"first","affiliation":[{"name":"Institute of Pathology Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabea","family":"Wagener","sequence":"additional","affiliation":[{"name":"Ulm University Medical Center Institute of Human Genetics Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"M\u04e7ller","sequence":"additional","affiliation":[{"name":"Institute of Pathology Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas F. E.","family":"Barth","sequence":"additional","affiliation":[{"name":"Institute of Pathology Ulm University Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,2,16]]},"reference":[{"volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","year":"2017","author":"Campo E","key":"e_1_2_7_2_1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27774"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.09.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25663"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1150"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05116-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2096"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3488"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2037511"},{"key":"e_1_2_7_11_1","first-page":"e6986","article-title":"A comprehensive microarray\u2010based DNA methylation study of 367","volume":"4","author":"Martin\u2010subero JI","year":"2009","journal-title":"Hematol Neoplasms"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3291"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1038"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz369"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9219"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:13:14Z","timestamp":1693555994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,16]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1111\/bjh.17193"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17193","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"type":"print","value":"0007-1048"},{"type":"electronic","value":"1365-2141"}],"subject":[],"published":{"date-parts":[[2021,2,16]]},"assertion":[{"value":"2020-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}