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The tumour begins on the inner aspect of the peri\u2010implant capsule causing an effusion, or less commonly a tissue mass to form within the capsule, which may spread locally or to more distant sites in the body. Diagnosis is usually made by cytological, immunohistochemical and immunophenotypic evaluation of the aspirated peri\u2010implant fluid: pleomorphic lymphocytes are characteristically anaplastic lymphoma kinase (ALK)\u2010negative and strongly positive for CD30. BIA\u2010ALCL is indolent in most patients but can progress rapidly. Surgical removal of the implant with the intact surrounding capsule (total en\u2010bloc capsulectomy) is usually curative. Late diagnosis may require more radical surgery and systemic therapies and although these are usually successful, poor outcomes and deaths have been reported. By adopting a structured approach, as suggested in these guidelines, early diagnosis and successful treatment will minimise the need for systemic treatments, reduce morbidity and the risk of poor outcomes.<\/jats:p>","DOI":"10.1111\/bjh.17194","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T21:50:10Z","timestamp":1606081810000},"page":"444-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["UK Guidelines on the Diagnosis and Treatment of Breast Implant\u2010Associated Anaplastic Large Cell Lymphoma on behalf of the Medicines and Healthcare products Regulatory Agency Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group"],"prefix":"10.1111","volume":"192","author":[{"given":"Philip","family":"Turton","sequence":"first","affiliation":[{"name":"St James's Hospital The Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dima","family":"El\u2010Sharkawi","sequence":"additional","affiliation":[{"name":"Royal Marsden NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Lyburn","sequence":"additional","affiliation":[{"name":"Cobalt Medical Charity Cheltenham UK"},{"name":"Gloucestershire Hospitals NHS Foundation Trust Gloucester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhupinder","family":"Sharma","sequence":"additional","affiliation":[{"name":"Royal Marsden NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethika","family":"Mahalingam","sequence":"additional","affiliation":[{"name":"Royal Marsden NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8439-4507","authenticated-orcid":false,"given":"Suzanne D.","family":"Turner","sequence":"additional","affiliation":[{"name":"Division of Cellular and Molecular Pathology Department of Pathology University of Cambridge Cambridge UK"},{"name":"CEITEC Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"MacNeill","sequence":"additional","affiliation":[{"name":"Royal Marsden NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Johnson","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Burton","sequence":"additional","affiliation":[{"name":"St James's Hospital The Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Mercer","sequence":"additional","affiliation":[{"name":"Bristol Plastic Surgery Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197046010-00001"},{"key":"e_1_2_9_3_1","unstructured":"Food and Drug Administration.FDA update on the safety of silicone gel\u2010filled breast implants 2011[cited 2020 April]. 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