{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:27:24Z","timestamp":1789014444519,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Routine follow\u2010up for diffuse large B\u2010cell lymphoma have been shortened to 2\u00a0years when event\u2010free survival at 24\u00a0months (EFS24) emerged as a new milestone. In the present study, we aimed to determine whether the achievement of this milestone affected overall survival (OS). We compared OS to that of an age\u2010 and sex\u2010matched population, analysed other factors governing OS, and reviewed the causes of death. Data were collected from the Swedish Cancer Registry and from individual patient\u2019s records. We included 1169 adult patients from five counties between the years 2001 and 2014. The median (range) age was 64\u00b76 (18\u201391) years, 56\u00b76% were men and the median follow\u2010up was 82\u00b73 months. For early stages, the achievement of EFS12 did not improve OS. More than two\u2010thirds of the patients (n = 837, 71\u00b76%) achieved EFS24, of which 190 (22\u00b77%) died during follow\u2010up. Lymphoma (20%), cardiovascular disease (22\u00b74%) and malignancies (16%) contributed to causes of death. Patients aged &lt;60 years had an OS that matched the standard population. In multivariate analysis, only age &gt;60 years significantly affected OS after EFS24 compared with the standard population. We concluded that follow\u2010up beyond EFS24 should be considered for patients aged &gt;60 years.<\/jats:p>","DOI":"10.1111\/bjh.17206","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T08:36:59Z","timestamp":1620203819000},"page":"906-914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Age is the most important predictor of survival in diffuse large B\u2010cell lymphoma patients achieving event\u2010free survival at 24 months: a Swedish population\u2010based study"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1942-3639","authenticated-orcid":false,"given":"Amal","family":"Abu Sabaa","sequence":"first","affiliation":[{"name":"Centre for Research and Development Uppsala University\/Region Gavleborg Sweden"},{"name":"Department of Immunology, Genetics and Pathology Experimental and Clinical Oncology Uppsala University 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