{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:52:13Z","timestamp":1789761133779,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The mucosa\u2010associated lymphoid tissue (MALT) International Prognostic Index (IPI) was recently proposed as a prognostic index for patients with MALT lymphoma. We aimed to investigate the prognostic value of the serum \u03b22\u2010microglobulin level in the context of MALT\u2010IPI, and we proposed a new prognostic index. Survival outcomes were analysed with regard to \u03b22\u2010microglobulin level, MALT\u2010IPI, and the new prognostic index in MALT lymphoma patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0571). The validity of the new prognostic index was assessed using an independent cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a0216). Patients with high \u03b22\u2010microglobulin levels had significantly worse progression\u2010free survival (PFS) and overall survival (OS) outcomes. A high \u03b22\u2010microglobulin level was independently associated with poor PFS and OS. \u03b22\u2010microglobulin levels further stratified patients in the MALT\u2010IPI intermediate\u2010risk group in terms of PFS and OS. A new prognostic index based on the MALT\u2010IPI and the \u03b22\u2010microglobulin level, MALT\u2010IPI\u2010B, was proposed. The MALT\u2010IPI\u2010B was able to stratify patients into subgroups having distinct PFS and OS outcomes in both the training and validation cohorts. MALT\u2010IPI\u2010B enabled the identification of patients with poor survival outcomes who were classified into the intermediate\u2010risk group by the MALT\u2010IPI. In conclusion, this new \u03b22\u2010microglobulin\u2010based prognostic index may have the specific advantage of identifying high\u2010risk patients who may require systemic treatment.<\/jats:p>","DOI":"10.1111\/bjh.17222","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T06:15:15Z","timestamp":1605939315000},"page":"307-315","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A prognostic index for extranodal marginal\u2010zone lymphoma based on the mucosa\u2010associated lymphoid tissue International Prognostic Index and serum \u03b22\u2010microglobulin levels"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9959-0642","authenticated-orcid":false,"given":"Hyung\u2010Don","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4307-2795","authenticated-orcid":false,"given":"Hyungwoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-6463","authenticated-orcid":false,"given":"Hyehyun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyunghye","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Oncology Asan Medical Center University of Ulsan College of Medicine Seoul Republic of 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