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We applied bioinformatics to identify new candidate genes associated with SCD\u2010related CKD. An interaction network demonstrated <jats:italic>APOA1<\/jats:italic> connecting haemoglobin subunit \u03b2 (<jats:italic>HBB<\/jats:italic>) and <jats:italic>APOL1<\/jats:italic> with 36 other candidate genes. Gene expression revealed upregulation of engulfment and cell motility 1 (<jats:italic>ELMO1<\/jats:italic>) and downregulation of <jats:italic>APOA1<\/jats:italic> in the kidney cortex of SCD <jats:italic>versus<\/jats:italic> non\u2010SCD mice. Analysis of candidate genes identified <jats:italic>ELMO1<\/jats:italic> rs10951509 to be associated with albuminuria and <jats:italic>APOA1<\/jats:italic> rs11216132 with haemoglobinuria in patients with SCD. A bioinformatic approach highlights <jats:italic>ELMO1<\/jats:italic> and <jats:italic>APOA1<\/jats:italic> as potentially associated with SCD nephropathy.<\/jats:p>","DOI":"10.1111\/bjh.17224","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T23:01:35Z","timestamp":1605913295000},"page":"628-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Engulfment and cell motility 1 (<i>ELMO1<\/i>) and apolipoprotein A1 (<i>APOA1<\/i>) as candidate genes for sickle cell nephropathy"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-4194","authenticated-orcid":false,"given":"Santosh L.","family":"Saraf","sequence":"first","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7732-1385","authenticated-orcid":false,"given":"Xu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binal N.","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Raslan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bamidele O.","family":"Tayo","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Loyola University Chicago Stritch School of Medicine Maywood IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Lash","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-7295","authenticated-orcid":false,"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"Division of Hematology and Oncology Department of Medicine University of Illinois at Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03940415"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2008.08.035"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010070730"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds369"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.005296"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"issue":"1","key":"e_1_2_5_10_1","first-page":"S1","article-title":"National Kidney Foundation. 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