{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:15:56Z","timestamp":1790601356889,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T00:00:00Z","timestamp":1606608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005304","name":"Agence Nationale pour le D\u00e9veloppement de la Recherche en Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005304","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Although most individuals with sickle cell disease (SCD) live in sub\u2010Saharan Africa, the natural history of the disease on this continent remains largely unknown. Intravascular haemolysis results in activation of circulating blood cells and release of microparticles (MPs) that exert pro\u2010inflammatory effects and contribute to vascular damage. We designed a case\u2010control study nested in the CADRE cohort (Coeur\u2010Art\u00e8re\u2010DR\u00c9panocytose, clinical trials.gov identifier NCTO3114137) and based on extreme phenotypes, to analyse blood cell\u2010derived MPs in 232 adult SS patients at steady state in Bamako and Dakar. Thirty\u2010six healthy adult controls matched by age and sex were recruited in Bamako. The MPs concentrations were higher in SS patients compared to AA controls with a predominance of erythrocyte\u2010 and reticulocyte\u2010derived MPs. These erythroid\u2010derived MPs were significantly lower in patients with retinopathy (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7022). Reticulocyte\u2010derived MPs were significantly negatively and positively associated with a history of priapism (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7020) and leg ulcers (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7041) respectively. We describe for the first time the comparative patterns of plasma MPs in healthy subjects and<\/jats:p><jats:p>patients with SCD living in sub\u2010Saharan Africa and exhibiting various complications. Because our present results show no clear pattern of correlation between erythroid MPs and the classical hyper\u2010haemolytic complications, we hypothesise a weak relevance of the hyper\u2010haemolysis <jats:italic>versus<\/jats:italic> hyper\u2010viscous paradigm in Africa.<\/jats:p>","DOI":"10.1111\/bjh.17242","type":"journal-article","created":{"date-parts":[[2020,11,29]],"date-time":"2020-11-29T08:48:58Z","timestamp":1606639738000},"page":"634-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cell\u2010derived microparticles and sickle cell disease chronic vasculopathy in sub\u2010Saharan Africa: A multinational study"],"prefix":"10.1111","volume":"192","author":[{"given":"Abdoul K.","family":"Demb\u00e9l\u00e9","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris UMR_S1134 Biologie Int\u00e9gr\u00e9e du Globule Rouge (BIGR) INSERM Paris France"},{"name":"Institut National de Transfusion Sanguine Paris France"},{"name":"Laboratoire d\u2019Excellence GR\u2010Ex Paris France"},{"name":"Centre de Recherche et de Lutte contre la Dr\u00e9panocytose (CRLD) Bamako Mali"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6665-3598","authenticated-orcid":false,"given":"Claudine","family":"Lapoumeroulie","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris UMR_S1134 Biologie Int\u00e9gr\u00e9e du Globule Rouge (BIGR) INSERM Paris France"},{"name":"Institut National de Transfusion Sanguine Paris France"},{"name":"Laboratoire d\u2019Excellence GR\u2010Ex Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mor","family":"Diaw","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Cheikh Anta Diop de Dakar (UCAD) Laboratoire de Physiologie et Explorations Fonctionnelles Dakar S\u00e9n\u00e9gal"},{"name":"Unit\u00e9 Mixte Internationale (UMI 3189), \u2018Environnement, Sant\u00e9, 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