{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T19:12:16Z","timestamp":1781982736342,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T00:00:00Z","timestamp":1606262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasia derived from immature myeloid dendritic cells with the mitogen\u2010activated protein kinase (MAPK) pathway gene mutation. LCH is rarely fatal, but patients develop various permanent consequences (PCs). We report the frequencies of LCH\u2010related PCs in paediatric patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0317) treated by the JLSG\u201096\/02 AraC\u2010containing regimens. One\u2010third of LCH patients had at least one PC at a median follow\u2010up of 12\u00a0years. Central nervous system (CNS)\u2010related PCs (neurological and endocrinological) accounted for 21\u00b75%, non\u2010CNS\u2010related 16\u00b77%. We require novel therapeutic measures to further reduce the frequency of LCH\u2010related PCs.<\/jats:p>","DOI":"10.1111\/bjh.17243","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T12:07:34Z","timestamp":1606306054000},"page":"615-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Long\u2010term complications in uniformly treated paediatric Langerhans histiocytosis patients disclosed by 12 years of follow\u2010up of the JLSG\u201096\/02 studies"],"prefix":"10.1111","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-538X","authenticated-orcid":false,"given":"Kenichi","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Children\u2019s Cancer Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9168-5409","authenticated-orcid":false,"given":"Akira","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Jichi Medical University School of Medicine Shimotsuke Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Shioda","sequence":"additional","affiliation":[{"name":"Children\u2019s Cancer Center National Center for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Graduate School of Medical Science Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinsaku","family":"Imashuku","sequence":"additional","affiliation":[{"name":"Division of Laboratory Medicine Uji\u2010Tokushukai Medical Center Uji Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Japan LCH Study Group 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