{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:28:47Z","timestamp":1787502527980,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    There is a lack of data regarding treatment and prognosis for the growing group of oldest old patients with lymphoma. Therefore, we studied 2347 patients aged \u226585\u00a0years from the Danish and Swedish lymphoma registers 2000\u20132016 (Denmark) and 2007\u20132013 (Sweden). Outcome was assessed using relative survival (RS). The 2\u2010year RS overall for patients with aggressive lymphomas was 38% [95% confidence interval (CI) 35\u201342%], of whom 845 (66%) patients received active treatment (chemotherapy, radiotherapy, immunotherapy, other). For aggressive lymphomas, not receiving active treatment was associated with an inferior 2\u2010year RS of 12% (95% CI 9\u201317%) compared to 49% (95% CI 45\u201353%) for patients who received active treatment (excess mortality rate ratio 2\u00b784, 95% CI 2\u00b73\u20133\u00b75;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b70001). For patients with indolent lymphoma, the 2\u2010year RS was 77% (95% CI 72\u201382%). Here, 383 (46%) patients received active treatment at diagnosis, but did not have better 2\u2010year RS (75%, 95% CI 67\u201381%) compared to those who did not receive active treatment (83%, 95% CI 74\u201389%). We conclude that outcomes for the oldest old patients with lymphoma are encouraging for several subtypes and that active treatment is associated with improved outcome amongst the oldest old patients with aggressive lymphomas, indicating that age itself should not be a contraindication to treatment.\n                  <\/jats:p>","DOI":"10.1111\/bjh.17250","type":"journal-article","created":{"date-parts":[[2020,11,25]],"date-time":"2020-11-25T02:13:48Z","timestamp":1606270428000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical characteristics and outcomes among 2347 patients aged \u226585\u00a0years with major lymphoma subtypes: a Nordic Lymphoma Group study"],"prefix":"10.1111","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-0349","authenticated-orcid":false,"given":"Tove","family":"W\u00e4sterlid","sequence":"first","affiliation":[{"name":"Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Haematology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5611-2031","authenticated-orcid":false,"given":"Kim","family":"Oren Gradel","sequence":"additional","affiliation":[{"name":"Centre for Clinical Epidemiology OUH and Institute of Clinical Research University of Southern Denmark Odense Denmark"},{"name":"OPEN\u2013 Odense Patient Data Exploratory Network Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-0573","authenticated-orcid":false,"given":"Sandra","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-3041","authenticated-orcid":false,"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Immunology, Genetics and Pathology Unit of Oncology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarec C.","family":"El\u2010Galaly","sequence":"additional","affiliation":[{"name":"Department of Hematology Aalborg University Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital (OUH) Odense Denmark"},{"name":"Academy of Geriatric Cancer Research Odense University Hospital Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Department of Medicine Solna Division of Clinical Epidemiology Karolinska Institutet and Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Haematology Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,24]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"An Aging world: 2015. 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