{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:07:07Z","timestamp":1792523227790,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>No data on inotuzumab ozogamicin (InO) in infant acute lymphoblastic leukaemia (ALL) have been published to date. We collected data internationally on infants\/young children (&lt;3\u00a0years) with ALL treated with InO. Fifteen patients (median 4.4 months at diagnosis) received InO due to relapsed or refractory (R\/R) disease. Median percentage of CD22<jats:sup>+<\/jats:sup> blasts was 72% (range 40\u2013100%, <jats:italic>n<\/jats:italic>\u00a0=\u00a09). The median dose in the first course was 1.74\u00a0mg\/m<jats:sup>2<\/jats:sup> (fractionated). Seven patients (47%) achieved complete remission; one additional minimal residual disease (MRD)\u2010positive patient became MRD\u2010negative. Six\u2010month overall survival was 47% (95% confidence interval [CI] 27\u201380%). Two patients developed veno\u2010occlusive disease after transplant. Further evaluation of InO in this subgroup of ALL is justified.<\/jats:p>","DOI":"10.1111\/bjh.17333","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T04:17:56Z","timestamp":1612585076000},"page":"1172-1177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Inotuzumab ozogamicin in infants and young children with relapsed or refractory acute lymphoblastic leukaemia: a case series"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5285-1702","authenticated-orcid":false,"given":"Erica","family":"Brivio","sequence":"first","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"},{"name":"Department of Pediatric Oncology\/Hematology Erasmus MC\u2010Sophia Children\u2019s Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe F.","family":"Chantrain","sequence":"additional","affiliation":[{"name":"Division of Pediatric Hematology Oncology CHC\u2010Clinique du MontL\u00e9gia \u2010 Li\u00e8ge Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja A.","family":"Gruber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford School of Medicine Stanford CA USA"},{"name":"Stanford Cancer Institute Stanford School of Medicine Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Thano","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Rialland","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology CHU de Nantes Nantes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Contet","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology Children\u2019s Hospital CHRU Nancy Vandoeuvre L\u00e8s Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Elitzur","sequence":"additional","affiliation":[{"name":"Pediatric Hematology \u2013Oncology Schneider Children's Medical Center of Israel Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Dalla\u2010Pozza","sequence":"additional","affiliation":[{"name":"Cancer Centre for Children The Children\u2019s Hospital at Westmead Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriszti\u00e1n Mikl\u00f3s","family":"K\u00e1llay","sequence":"additional","affiliation":[{"name":"Pediatric Hematology and Stem Cell Transplantation Department Central Hospital of Southern Pest \u2013 National Institute of Hematology and Infectious Diseases Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010kong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Paediatrics The Chinese University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Oncology Research National Research Institute for Child Health and Development Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Markova","sequence":"additional","affiliation":[{"name":"R.M. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation Pavlov University Saint\u2010Petersburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine Rigshospitalet Copenhagen University Hospital; Institute of Clinical Medicine Faculty of Health, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Bodmer","sequence":"additional","affiliation":[{"name":"Department Oncology University Children's Hospital Z\u00fcrich Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin H.","family":"Breese","sequence":"additional","affiliation":[{"name":"Division of Oncology, Cancer and Blood Diseases Institute Cincinnati Children\u2019s Hospital Medical Center; Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoull","family":"Hoogendijk","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Michel","family":"Zwaan","sequence":"additional","affiliation":[{"name":"Princess M\u00e1xima Center for Pediatric Oncology Utrecht the Netherlands"},{"name":"Department of Pediatric Oncology\/Hematology Erasmus MC\u2010Sophia Children\u2019s Hospital Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.64.6364"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.00261"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.279"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-128977"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-134774"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0265-z"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509277"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21975"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16732"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25410"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-018-9614-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.3301"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019004008"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:07:34Z","timestamp":1693364854000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/bjh.17333"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17333","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]},"assertion":[{"value":"2020-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}