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AML was <jats:italic>de novo<\/jats:italic> in 58%, therapy\u2010related (t\u2010AML) in 37% and secondary after myelodysplastic syndrome (s\u2010AML) in 5%. Cytogenetics revealed a complex karyotype in 43%. Besides <jats:italic>MYST3\u2013CREBBP<\/jats:italic>, whole\u2010genome sequencing on a subset of 10 patients revealed recurrent mutations in <jats:italic>ASXL1<\/jats:italic>, <jats:italic>BRD3<\/jats:italic>, <jats:italic>FLT3<\/jats:italic>, <jats:italic>MLH1<\/jats:italic>, <jats:italic>POLG<\/jats:italic>, <jats:italic>TP53<\/jats:italic>, <jats:italic>SAMD4B<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a03, each), <jats:italic>EYS<\/jats:italic>, <jats:italic>KRTAP9\u20101 SPTBN5<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a04, each), <jats:italic>RUNX1<\/jats:italic> and <jats:italic>TET2<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a02, each). Complete remission after intensive chemotherapy was achieved in 84%. Median follow\u2010up was 5\u00b748\u00a0years; five\u2010year survival rate was 17%. Patients with s\u2010\/t\u2010AML (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701) and those with complex karyotype (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704) had an inferior prognosis. Allogeneic haematopoietic cell transplantation (allo\u2010HCT) was performed in 21 (36%) patients, including 15 in first complete remission (CR1). Allo\u2010HCT in CR1 significantly improved survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704); multivariable analysis revealed that allo\u2010HCT in CR1 was effective in <jats:italic>de novo<\/jats:italic> AML but not in patients with s\u2010AML\/t\u2010AML and less in patients exhibiting a complex karyotype. In summary, outcomes of patients with t(8;16) are dismal with chemotherapy, and may be substantially improved with allo\u2010HCT performed in CR1.<\/jats:p>","DOI":"10.1111\/bjh.17336","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T04:17:36Z","timestamp":1612585056000},"page":"832-842","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study*"],"prefix":"10.1111","volume":"192","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-8843","authenticated-orcid":false,"given":"Sabine","family":"Kayser","sequence":"first","affiliation":[{"name":"Medical Clinic and Policlinic I, Hematology and Cellular Therapy University Hospital Leipzig Leipzig Germany"},{"name":"NCT Trial Center National Center of Tumor Diseases German Cancer Research Center (DKFZ) 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