{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:33:01Z","timestamp":1771054381902,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The expression patterns and prognostic significance of sterile alpha motif and HD domain\u2010containing protein 1 (SAMHD1) protein in the neoplastic Hodgkin and Reed Sternberg (HRS) cells of Hodgkin lymphoma (HL) were investigated in a cohort of 154 patients with HL treated with standard regimens. SAMHD1 expression was assessed by immunohistochemistry using diagnostic lymph node biopsies obtained prior to treatment. Using an arbitrary 20% cut\u2010off, SAMHD1 was positive in HRS cells of 48\/154 (31\u00b72%) patients. SAMHD1 expression was not associated with clinicopathologic parameters, such as age, gender, stage or histologic subtype. In 125 patients with a median follow\u2010up of 90\u00a0months (7\u2013401\u00a0months), SAMHD1 expression in HRS cells significantly correlated with inferior freedom from progression (FFP) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7025), disease\u2010specific survival (DSS) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013) and overall survival (OS) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701). Importantly, in multivariate models together with disease stage, histology subtype and type of treatment as covariates, SAMHD1 expression retained an independent significant association with unfavourable FFP (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) as well as DSS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7022) and OS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018). These findings uncover the significance of a novel, adverse prognostic factor in HL that may have therapeutic implications since SAMHD1 inhibitors are now available for clinical use.<\/jats:p>","DOI":"10.1111\/bjh.17352","type":"journal-article","created":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T18:32:10Z","timestamp":1612549930000},"page":"488-496","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Expression of the novel tumour suppressor sterile alpha motif and HD domain\u2010containing protein 1 is an independent adverse prognostic factor in classical Hodgkin lymphoma"],"prefix":"10.1111","volume":"193","author":[{"given":"Ioanna","family":"Xagoraris","sequence":"first","affiliation":[{"name":"Department of Oncology\u2010Pathology Karolinska Institute Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros P.","family":"Vassilakopoulos","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation National and Kapodistrian University of Athens Laikon General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Drakos","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Crete Medical School Heraklion Crete Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria K.","family":"Angelopoulou","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation National and Kapodistrian University of Athens Laikon General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-6142","authenticated-orcid":false,"given":"Fotios","family":"Panitsas","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation National and Kapodistrian University of Athens Laikon General Hospital Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolas","family":"Herold","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Karolinska Institute Stockholm Sweden"},{"name":"Theme Paediatrics Paediatric Oncology Karolinska University Hospital Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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