{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:50:06Z","timestamp":1790686206904,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T00:00:00Z","timestamp":1614038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ibrutinib is an established treatment for relapsed\/refractory (R\/R) mantle cell lymphoma (MCL) and clinical trial data supports use at second line compared to later relapse. We aimed to investigate outcomes and tolerability for ibrutinib when given second line in a real\u2010world setting. Our multicentre retrospective analysis included 211 R\/R MCL patients, median age 73\u00a0years, receiving ibrutinib second\u2010line within the United Kingdom\u2019s National Health Service. Overall response to ibrutinib was 69% (complete response 27%). The median progression\u2010free survival (PFS) was 17\u00b78\u00a0months (95% CI 13\u00b71\u201322\u00b72) and median overall survival (OS) 23\u00b79\u00a0months (95% CI 15\u00b70\u201332\u00b78). Drug\u2010related adverse event led to dose reduction in 10% of patients and discontinuation in 5%. In patients with progressive disease, accounting for 100 of 152 patients stopping ibrutinib, 43% received further systemic therapy. Post\u2010ibrutinib rituximab, bendamustine and cytarabine (R\u2010BAC) showed a trend toward improved survival compared to alternative systemic treatments (post\u2010ibrutinib median OS 14\u00b70\u00a0months, 95% CI 8\u00b71\u201319\u00b78, vs. 3\u00b76\u00a0months, 95% CI 2\u00b76\u20134\u00b75, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b706). Our study confirms the clinical benefit and good tolerability of ibrutinib at first relapse in a real\u2010world population. Patients progressing on ibrutinib had limited survival but outcomes with R\u2010BAC in select patients were promising.<\/jats:p>","DOI":"10.1111\/bjh.17363","type":"journal-article","created":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T12:14:06Z","timestamp":1614082446000},"page":"290-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Ibrutinib for mantle cell lymphoma at first relapse: a United Kingdom real\u2010world analysis of outcomes in 211 patients"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0090-7174","authenticated-orcid":false,"given":"Rory","family":"McCulloch","sequence":"first","affiliation":[{"name":"University Hospitals Plymouth NHS Trust Plymouth United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lewis","sequence":"additional","affiliation":[{"name":"University Hospitals Plymouth NHS Trust Plymouth 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