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A better understanding of the complex biology of MCL has already led to the approval of several innovative agents, expanding the landscape of MCL therapies and improving therapeutic options especially for refractory\/relapsed (R\/R) disease.<\/jats:p><jats:p>Nevertheless, to further optimise MCL treatment, early identification of individual risk profile and risk\u2010adapted, patient\u2010tailored choice of therapeutic strategy needs to be prospectively incorporated into clinical patient management. The present review highlights recent advances in deciphering the molecular background of MCL, the definition of prognostically relevant factors and the identification of potential druggable targets and summarises current treatment recommendations for primary and R\/R MCL including novel targeted therapies.<\/jats:p>","DOI":"10.1111\/bjh.17419","type":"journal-article","created":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T09:11:20Z","timestamp":1617095480000},"page":"162-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Mantle cell lymphoma \u2013 advances in molecular biology, prognostication and treatment approaches"],"prefix":"10.1111","volume":"195","author":[{"given":"Elisabeth","family":"Silkenstedt","sequence":"first","affiliation":[{"name":"Department of Medicine III LMU Hospital Munich 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