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Here, we present patient\u2010reported outcomes (PROs) from POLLUX, assessed using the validated European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30\u2010item (EORTC QLQ\u2010C30) and the EuroQol 5\u2010dimensional descriptive system (EQ\u20105D\u20105L) questionnaires. Changes from baseline are presented as least\u2010squares mean changes with 95% confidence intervals (CIs) derived from a mixed\u2010effects model. PRO assessment compliance rates were high and similar in both D\u2010Rd and Rd groups through cycle 40 (week 156). In this on\u2010treatment analysis, mean changes from baseline were significantly greater in EORTC QLQ\u2010C30 global health status, physical functioning, and pain scores in the D\u2010Rd group <jats:italic>versus<\/jats:italic> the Rd group at multiple time points; however, magnitude of changes was low, suggesting no meaningful impact on health\u2010related quality of life (HRQoL). Subgroup results were similar to those in the overall population. In the POLLUX study, baseline HRQoL was maintained with prolonged D\u2010Rd treatment. These findings complement the sustained and significant improvement in progression\u2010free survival observed with D\u2010Rd and supports its use in patients with RRMM.<\/jats:p><jats:p>Clinical trial registration: NCT02076009.<\/jats:p>","DOI":"10.1111\/bjh.17435","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T11:03:59Z","timestamp":1617707039000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Health\u2010related quality of life in patients with relapsed or refractory multiple myeloma: treatment with daratumumab, lenalidomide, and dexamethasone in the phase 3 POLLUX trial"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2340-6068","authenticated-orcid":false,"given":"Torben","family":"Plesner","sequence":"first","affiliation":[{"name":"Vejle Hospital and University of Southern Denmark Vejle 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