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A cohort of 74 patients with HCL was divided in to three groups: (A) patients aged &gt;65\u00a0years with first\u2010line treatment; (B) patients with comorbidities with first\u2010line treatment; (C) patients who were purine analogues resistant. In total, 94% achieved a response, with a complete response rate of 24%. After a median (range) follow\u2010up of 60\u00a0(7\u2013236)\u00a0months, 55 patients (78%) are still responding. The 5\u2010year progression\u2010free survival was 95%, 68%, and 96% in groups A, B and C respectively. A proportion of patients were monitored through their B\u2010Raf proto\u2010oncogene, serine\/threonine kinase (<jats:italic>BRAF<\/jats:italic>)\u2010V600E status. IFN\u03b1 remains a possible option in select patients with HCL, where minimal residual disease negativity is achievable.<\/jats:p>","DOI":"10.1111\/bjh.17440","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T09:12:07Z","timestamp":1619860327000},"page":"78-82","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The current role of interferon in hairy cell leukaemia: clinical and molecular aspects"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6190-9635","authenticated-orcid":false,"given":"Giovanni M.","family":"Assanto","sequence":"first","affiliation":[{"name":"Haematology Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costantino","family":"Riemma","sequence":"additional","affiliation":[{"name":"Haematology Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy"},{"name":"Haematology and Stem Cell Transplant Unit IRCCS Centro di Riferimento Oncologico della Basilicata Rionero in Vulture Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Malaspina","sequence":"additional","affiliation":[{"name":"Haematology Department of Translational and Precision Medicine Sapienza University of Rome Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8196-0481","authenticated-orcid":false,"given":"Salvatore","family":"Perrone","sequence":"additional","affiliation":[{"name":"Haematology Unit S. 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