{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:08:08Z","timestamp":1773788888986,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recently, the use of targeted synthetic or biological disease\u2010modifying anti\u2010rheumatic drugs (ts\/bDMARDs) in addition to conventional synthetic (cs)DMARDs including methotrexate (MTX) for rheumatoid arthritis (RA) has increased. However, whether ts\/bDMARDs are associated with the development and clinicopathological features of MTX\u2010associated lymphoproliferative disorder (MTX\u2010LPD) in patients with RA remains unknown. Therefore, we evaluated the clinical outcomes of 121 patients with MTX\u2010LPD. Results showed that prior use of ts\/bDMARDs was not associated with the different histopathological subtypes of MTX\u2010LPD. Patients with polymorphic\u2010type LPD had a better event\u2010free survival than those with diffuse large B\u2010cell lymphoma (DLBCL), classical Hodgkin lymphoma and peripheral T\u2010cell lymphoma. The pathological subtype of lymphoma could predict the clinical outcome of MTX\u2010LPD. In patients with DLBCL, the use of tumour necrosis factor\u2010alpha (TNF\u2010\u03b1) inhibitors prior to MTX\u2010LPD onset was associated with a higher non\u2010relapse mortality. Further, patients with RA previously treated with Janus kinase (JAK) inhibitors more commonly required chemotherapy than those treated with csDMARDs alone, indicating disease aggressiveness. Hence, special caution should be observed when managing patients with MTX\u2010LPD previously treated with JAK or TNF\u2010\u03b1 inhibitors for RA.<\/jats:p>","DOI":"10.1111\/bjh.17456","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T10:31:50Z","timestamp":1617705110000},"page":"101-110","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Outcomes of methotrexate\u2010associated lymphoproliferative disorders in rheumatoid arthritis patients treated with disease\u2010modifying anti\u2010rheumatic drugs"],"prefix":"10.1111","volume":"194","author":[{"given":"Takuya","family":"Harada","sequence":"first","affiliation":[{"name":"Department of Medicine and Biosystemic Science Kyushu University Graduate School of Medical Science Fukuoka Japan"},{"name":"Department of Haematology National Hospital Organisation Kyushu Medical Centre Fukuoka 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