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Considered an incurable but treatable disease, MF\/SS management presents several challenges including diagnostic delays, debilitating effect on patients\u2019 quality of life, need for several lines of therapies, multidisciplinary care and cumulative drug toxicities limiting duration of use. The present review intends to provide an overview of the recent advances in our understanding of the biology of CTCL and how these are being leveraged to provide additional treatment options for management of advanced and recurrent disease. In addition, the discussion of the different modalities of treatment is summarised to further outline the importance of multidisciplinary care and early referral to CTCL centres.<\/jats:p>","DOI":"10.1111\/bjh.17458","type":"journal-article","created":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T07:01:08Z","timestamp":1620975668000},"page":"352-364","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["How we treat advanced stage cutaneous T\u2010cell lymphoma \u2013 mycosis fungoides and S\u00e9zary syndrome"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1346-2103","authenticated-orcid":false,"given":"Tarsheen K.","family":"Sethi","sequence":"first","affiliation":[{"name":"Division of Hematology Yale University School of Medicine New Haven CT 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