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It is associated with impressive disease responses in relapsed or refractory high\u2010grade B\u2010cell non\u2010Hodgkin lymphoma (B\u2010NHL) and acute lymphoblastic leukaemia (B\u2010ALL) with durable remissions in a subset of patients. Historically, haematopoietic cell transplantation (HCT) has been the standard consolidation strategy for many of these patients who are now being treated with CAR T. Relapses are frequent after CD19 CAR T therapy in B\u2010ALL and consolidation with allogeneic HCT (allo\u2010HCT) may improve survival of patients with high\u2010risk disease. There appears to be a clear difference in B\u2010ALL outcomes between paediatric and adult patients, with the latter having a much higher risk of relapse after CAR T therapy. Late relapses are infrequent in patients with B\u2010NHL and consolidation with allo\u2010HCT may not be needed in patients who achieve a complete remission after CAR T therapy. Future registry\u2010based and prospective studies will hopefully provide the needed data in the future to risk\u2010stratify the recipients of CAR T therapy. Meanwhile, we provide guidance on patient selection and practical issues with performing allo\u2010HCT after CAR T therapy.<\/jats:p>","DOI":"10.1111\/bjh.17460","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T02:19:26Z","timestamp":1619749166000},"page":"1060-1075","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The evolving role of allogeneic haematopoietic cell transplantation in the era of chimaeric antigen receptor T\u2010cell therapy"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2371-3655","authenticated-orcid":false,"given":"Bhagirathbhai","family":"Dholaria","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bipin N.","family":"Savani","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University Institute of Hematology Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Chaim Sheba Medical Center Tel Hashomer, Israel ALWP Office H\u00f4pital Saint\u2010Antoine Paris France"},{"name":"EBMT ALWP Office H\u00f4pital Saint\u2010Antoine Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5910-4571","authenticated-orcid":false,"given":"Miguel\u2010Angel","family":"Perales","sequence":"additional","affiliation":[{"name":"Adult Bone Marrow Transplant Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8536-7781","authenticated-orcid":false,"given":"Mohamad","family":"Mohty","sequence":"additional","affiliation":[{"name":"EBMT ALWP Office H\u00f4pital Saint\u2010Antoine Paris France"},{"name":"Service d\u2019H\u00e9matologie Clinique et Th\u00e9rapie Cellulaire H\u00f4pital Saint\u2010Antoine AP\u2010HP Sorbonne University INSERM UMRs 938 Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"D'SouzaAZX.CIBMTR Summary Slides \u2010 HCT Trends and Survival Data.2017. 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