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Allogeneic haematopoietic stem cell transplantation (HSCT) offers an important curative treatment option for primary MF and post\u2010essential thrombocythaemia\/polycythaemia vera MF or secondary MF. With a disease course that varies from indolent to highly progressive, we are now able to stratify risk of mortality through various tools including patient\u2010related clinical characteristics as well as molecular genetic profile. Owing to the high risk of mortality and morbidity associated with HSCT for patients with myelofibrosis, it is important to improve patient selection for transplant. Our primary goal is to comprehensively define our understanding of current practices including the role of Janus Kinase (JAK) inhibitors, to present the data behind transplantation before and after leukaemic transformation, and to introduce novel personalization of MF treatment with a proposed clinical\u2010molecular prognostic model to help elucidate a timepoint optimal for consideration of HSCT.<\/jats:p>","DOI":"10.1111\/bjh.17469","type":"journal-article","created":{"date-parts":[[2021,4,22]],"date-time":"2021-04-22T02:17:07Z","timestamp":1619057827000},"page":"495-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Allogeneic haematopoietic cell transplantation for myelofibrosis: a real\u2010life 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