{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:16:58Z","timestamp":1779297418524,"version":"3.51.4"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    In this retrospective study, we investigated the influence of chemotherapy and immunotherapy on thromboembolic risk among United States Veterans with lung cancer during their first 6\u00a0months (180\u00a0days) following initiation of systemic therapy. Included patients received treatment with common front\u2010line agents that were divided into four groups: chemotherapy alone, immunotherapy alone, combination of chemo\u2010 and immunotherapies, and molecularly targeted therapies (control group). The cohort experienced a 7\u00b74% overall incidence of thrombosis, but the analysis demonstrated significantly different rates among the different groups. We explored models incorporating multiple confounding variables as well as the competing risk of death, and these results indicated that both chemo\u2010 and immunotherapies were associated with an increased incidence of thrombosis, either alone or combined, compared with the control group (7\u00b756%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a02.2\u00a0\u00d7\u00a010\n                    <jats:sup>\u201316<\/jats:sup>\n                    ; 10\u00b72%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a02.2\u00a0\u00d7\u00a010\n                    <jats:sup>\u201316<\/jats:sup>\n                    ; and 7\u00b787%,\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a02.4\u00a0\u00d7\u00a010\n                    <jats:sup>\u201314<\/jats:sup>\n                    respectively vs. 4\u00b710%). The Khorana score was found to be associated with increased risk, as were vascular disease and metastases. We found an association between risk of thrombosis and the use of anticoagulation, accounting for several confounders, including history of thrombosis. Further study is warranted to better determine the drivers of thromboembolic risk and to identify ways to mitigate this risk for patients.\n                  <\/jats:p>","DOI":"10.1111\/bjh.17476","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T02:20:27Z","timestamp":1623896427000},"page":"179-190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Thromboembolic risk in patients with lung cancer receiving systemic therapy"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-0414","authenticated-orcid":false,"given":"Cecelia J.","family":"Madison","sequence":"first","affiliation":[{"name":"VA Portland Healthcare System Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan A.","family":"Melson","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Conlin","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System Portland OR USA"},{"name":"Oregon Health and Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-0561","authenticated-orcid":false,"given":"Kenneth R.","family":"Gundle","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System Portland OR USA"},{"name":"Oregon Health and Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-5296","authenticated-orcid":false,"given":"Reid F.","family":"Thompson","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System Portland OR USA"},{"name":"Oregon Health and Science University Portland OR USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Calverley","sequence":"additional","affiliation":[{"name":"VA Portland Healthcare System Portland OR USA"},{"name":"BC Cancer Agency Vancouver Centre and Division of Medical Oncology University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605883"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-08-0615"},{"key":"e_1_2_6_4_1","first-page":"CD008500","article-title":"Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy","volume":"12","author":"Di Nisio M","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198802183180703"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.2.286"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24596"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2016.10.007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.809"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2016.05.021"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2017.0050"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.6065"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw326"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501824"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/amiajnl-2011-000116"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S47150"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000182534.19832.83"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntr206"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/1460458219882259"},{"key":"e_1_2_6_23_1","unstructured":"KassambaraA KosinskiM BiecekP FabianS.suvminer: Drawing Survival Curves using \u2018ggplot2\u2019.2020. Available at:https:\/\/CRAN.R\u2010project.org\/package=survminer"},{"key":"e_1_2_6_24_1","unstructured":"R Core Team. R.A language and environment for statistical computing. R Foundation for Statistical Computing.2020.https:\/\/www.R\u2010project.org\/"},{"key":"e_1_2_6_25_1","unstructured":"GrayB.cmprsk: Subdistribution Analysis of Competing Risks.2020.https:\/\/CRAN.R\u2010project.org\/package=cmprsk"},{"key":"e_1_2_6_26_1","unstructured":"LesnoffM LancelotR aod: Analysis of Overdispersed Data.2012.https:\/\/CRAN.R\u2010project.org\/package=aod"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2009.359"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.5669"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e3283100e9c"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.4274"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2003.191"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2016-0246"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001719"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007878"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010067"},{"issue":"1","key":"e_1_2_6_39_1","first-page":"4864","article-title":"Incidence of vascular thromboembolic events in patients receiving immunotherapy: a single institution experience","volume":"130","author":"Ibrahini S","year":"2017","journal-title":"Blood"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0205"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13378"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13594"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17476","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17476","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T01:56:27Z","timestamp":1692842187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/bjh.17476"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17476","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.12.21.20248675","asserted-by":"object"}]},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]},"assertion":[{"value":"2020-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}