{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:01:48Z","timestamp":1781002908933,"version":"3.54.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T00:00:00Z","timestamp":1621296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["SA 312044"],"award-info":[{"award-number":["SA 312044"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Population\u2010based studies on familial aggregation of haematological malignancies (HM) have rarely focused specifically on early\u2010onset HMs. We estimated standardized incidence ratios (SIR) and cumulative risks of relatives with Hodgkin lymphoma (HL), non\u2010Hodgkin lymphomas (NHL), acute lymphoblastic leukaemia\/lymphoma (ALL\/LBL) and acute myeloid leukaemia (AML) when index persons and relatives were diagnosed with early\u2010onset HM. A total of 8791 patients aged \u226440\u00a0years and diagnosed with primary HM in Finland from 1970 to 2012 were identified from the Finnish Cancer Registry and their 75\u00a0774 family members were retrieved from the population registry. SIRs for concordant HMs were elevated among first\u2010degree relatives in all of the most common HMs of children and adolescents and young adults (AYA). The risk was highest among siblings with HL (SIR 9\u00b709, 95% confidence interval 5\u00b755\u201314\u00b704) and AML (8\u00b729, 1\u00b700\u201329\u00b796). HL also had the highest cumulative risk for siblings at \u226440\u00a0years of age (0\u00b792% vs. 0\u00b711% in the population). In conclusion, significantly elevated SIRs indicate a role of shared aetiological factors in some families, which should be noted in the clinical setting when caring for patients with early\u2010onset HMs.<\/jats:p>","DOI":"10.1111\/bjh.17477","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T07:41:08Z","timestamp":1621323668000},"page":"1134-1141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Familial aggregation of early\u2010onset haematological malignancies"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0269-0167","authenticated-orcid":false,"given":"Rosa","family":"R\u00f6nkk\u00f6","sequence":"first","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Helsinki Finland"},{"name":"Department of Internal Medicine Helsinki University Hospital Helsinki Finland"},{"name":"Department of Hematology University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elli","family":"Hirvonen","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8127-8087","authenticated-orcid":false,"given":"Nea","family":"Malila","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8467-2100","authenticated-orcid":false,"given":"Outi","family":"Kilpivaara","sequence":"additional","affiliation":[{"name":"Applied Tumor Genomics, Research Programs Unit, Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Medical and Clinical Genetics, Medicum, Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"HUSLAB Laboratory of Genetics HUS Diagnostic Center (Helsinki University Hospital) Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-2712","authenticated-orcid":false,"given":"Ulla","family":"Wartiovaara\u2010Kautto","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Helsinki Helsinki Finland"},{"name":"Applied Tumor Genomics, Research Programs Unit, Faculty of Medicine University of Helsinki Helsinki Finland"},{"name":"Department of Hematology Helsinki University Hospital Comprehensive Cancer Center Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9879-6673","authenticated-orcid":false,"given":"Janne","family":"Pitk\u00e4niemi","sequence":"additional","affiliation":[{"name":"Finnish Cancer Registry Institute for Statistical and Epidemiological Cancer Research Helsinki Finland"},{"name":"Faculty of Social Sciences Tampere University Tampere Finland"},{"name":"Department of Public Health Clinicum Faculty of Medicine University of Helsinki Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1529428"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21448"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-641100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14829-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-015-0657-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-283093"},{"key":"e_1_2_8_8_1","unstructured":"Madanat\u2010HarjuojaL.Cancer in Finland 2016. Cancer in children and adolescents. [Internet]. Cancer Society of Finland. 2016 [Cited 2020 Oct 28]. Available from:https:\/\/www.cancersociety.fi\/publications\/reports\/cancer\u2010in\u2010finland\u20102016\/cancer\u2010in\u2010children\u2010and\u2010adolescents\/."},{"key":"e_1_2_8_9_1","unstructured":"NORDCAN.Association of the Nordic Cancer Registries. [Internet] [Cited 2020 Oct 28]. Available from:http:\/\/www\u2010dep.iarc.fr."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30583"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001362"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20189"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404378"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20989"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0010065"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-04-639781"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.5958"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0140"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji293"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.272"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0163"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2357::AID-CNCR21>3.0.CO;2-3"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12069"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29172"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.1203"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-858597"},{"issue":"7889","key":"e_1_2_8_27_1","first-page":"1","article-title":"Familial risk of early and late onset cancer: nationwide prospective cohort study","volume":"346","author":"Kharazmi E","year":"2013","journal-title":"BMJ"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0049-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017013037"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01590-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2010.06.001"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611604"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0243-5"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0864-9"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.02.017"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1638522"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32512"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-3233-2_14"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08267.x"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-670240"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-143602"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0341"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.279"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5628-y"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100710"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.12.013"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04989-w"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7691"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14175"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1127416"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1400972"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/08880018.2015.1020178"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23842"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(03)00628-2"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.1194"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24856"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bjh.17477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.17477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:06:29Z","timestamp":1693364789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.17477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,18]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/bjh.17477"],"URL":"https:\/\/doi.org\/10.1111\/bjh.17477","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,18]]},"assertion":[{"value":"2020-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}