{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:11:43Z","timestamp":1781525503762,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010137","name":"Fondation Sanofi Espoir","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Treatment benefit in multiple myeloma (MM) patients with high\u2010risk cytogenetics remains suboptimal. The phase 3 ICARIA\u2010MM trial (NCT02990338) showed that isatuximab plus pomalidomide\u2013dexamethasone prolongs median progression\u2010free survival (mPFS) in patients with relapsed\/refractory MM (RRMM). This subgroup analysis of ICARIA\u2010MM compared the benefit of isatuximab in high\u2010risk [defined by the presence of del(17p), t(4;14) or t(14;16)] <jats:italic>versus<\/jats:italic> standard\u2010risk patients. The efficacy of isatuximab in patients with gain(1q21) abnormality was also assessed in a retrospective subgroup analysis. In ICARIA\u2010MM, 307 patients received isatuximab\u2013pomalidomide\u2013dexamethasone (<jats:italic>n<\/jats:italic>\u00a0=\u00a0154) or pomalidomide\u2013dexamethasone (<jats:italic>n<\/jats:italic>\u00a0=\u00a0153). Isatuximab (10\u00a0mg\/kg intravenously) was given weekly in the first 28\u2010day cycle, and every other week thereafter. Standard pomalidomide\u2013dexamethasone doses were given. Isatuximab\u2013pomalidomide\u2013dexamethasone improved mPFS (7\u00b75 vs 3\u00b77\u00a0months; HR, 0\u00b766; 95% CI, 0\u00b733\u20131\u00b728) and overall response rate (ORR, 50\u00b70% vs 16\u00b77%) in high\u2010risk patients. In patients with isolated gain(1q21), isatuximab addition improved mPFS (11\u00b72 vs 4\u00b76\u00a0months; HR, 0\u00b750; 95% CI, 0\u00b728\u20130\u00b788) and ORR (53\u00b76% vs 27\u00b76%). More grade \u22653 adverse events occurred in high\u2010risk patients receiving isatuximab (95\u00b77%) <jats:italic>versus<\/jats:italic> the control group (67\u00b76%); however, isatuximab did not increase events leading to discontinuation or treatment\u2010related mortality. Isatuximab\u2013pomalidomide\u2013dexamethasone provides a consistent benefit over pomalidomide\u2013dexamethasone treatment in RRMM patients regardless of cytogenetic risk.<\/jats:p>","DOI":"10.1111\/bjh.17499","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T06:04:01Z","timestamp":1622009041000},"page":"120-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Subgroup analysis of ICARIA\u2010MM study in relapsed\/refractory multiple myeloma patients with high\u2010risk cytogenetics"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-6582","authenticated-orcid":false,"given":"Simon J.","family":"Harrison","sequence":"first","affiliation":[{"name":"Peter MacCallum Cancer Centre and Royal Melbourne Hospital Melbourne Victoria 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