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One of such events is the mitochondria clearance that occurs cell\u2010autonomously via autophagy\u2010dependent mechanisms. Interestingly, recent studies have shown mitochondria transfer activities between various cell types. In the context of erythropoiesis, macrophages are known to interact closely with the early stages of erythroblasts to provide a specialized niche, termed erythroblastic islands (EBI). However, whether mitochondria transfer can occur in the EBI niche has not been explored. Here, we report that mitochondria transfer in the EBI niche occurs <jats:italic>in vivo<\/jats:italic>. We observed mitochondria transfer activities from the early stages of erythroblasts to macrophages in the reconstituted <jats:italic>in vitro<\/jats:italic> murine EBI via different modes, including tunnelling nanotubes (TNT). Moreover, we demonstrated that Wiskott\u2010Aldrich syndrome protein (WASp) in macrophages mediates TNT formation and mitochondria transfer via the modulation of F\u2010actin filamentation, thus promoting mitochondria clearance from erythroid cells, to potentially enhance their differentiation. Taken together, our findings provide novel insight into the mitochondria clearance machineries that mediate erythroid maturation.<\/jats:p>","DOI":"10.1111\/bjh.17531","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T05:38:38Z","timestamp":1622007518000},"page":"1260-1274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Mitochondria transfer from early stages of erythroblasts to their macrophage niche via tunnelling nanotubes"],"prefix":"10.1111","volume":"193","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-3970","authenticated-orcid":false,"given":"Chong","family":"Yang","sequence":"first","affiliation":[{"name":"Cancer Science Institute of Singapore Yong Loo Lin School of Medicine National University of Singapore Singapore 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