{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:58:25Z","timestamp":1780084705171,"version":"3.54.0"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Follicular lymphomas (FLs) with <jats:italic>MYC<\/jats:italic> rearrangements (<jats:italic>MYC<\/jats:italic>\u2010R) and extra copies of <jats:italic>MYC<\/jats:italic> (<jats:italic>MYC<\/jats:italic>\u2010EC) are rare and the prognosis impact is uncertain. We conducted a retrospective study including 321 FL patients, among whom 259 (81%) had no 8q24 alterations and 62 (19%) were assigned to 8qAlt. Forty\u2010five cases were classified as <jats:italic>MYC<\/jats:italic>\u2010EC and six as <jats:italic>MYC<\/jats:italic>\u2010R. <jats:italic>MYC<\/jats:italic>\u2010R patients were significantly older (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008), had higher follicular lymphoma international prognostic index (FLIPI) stage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705) and \u03b22\u2010microglobulin (\u03b22m; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705). Among patients treated with immuno\u2010chemotherapy, four presented a <jats:italic>MYC<\/jats:italic>\u2010R and 25 a <jats:italic>MYC<\/jats:italic>\u2010EC. Univariate analysis showed the absence of significant difference between <jats:italic>MYC<\/jats:italic>\u2010EC and normal <jats:italic>MYC<\/jats:italic> (<jats:italic>MYC<\/jats:italic>\u2010NL) regarding progression\u2010free survival (PFS; HR1\u00b73; 95% CI [0\u00b74\u20131\u00b76]) and specific overall survival (SOS; HR 1\u00b76; 95% CI [0\u00b74\u20135\u00b77]). Those results were compared to data from the PRIMA trial. This confirmed that <jats:italic>MYC<\/jats:italic>\u2010EC had no impact on PFS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b786) or SOS (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b79). Conversely, <jats:italic>MYC<\/jats:italic>\u2010R was associated with a trend to inferior outcome regarding PFS (HR : 6\u00b71; 95% CI [2\u00b72\u201317\u00b71]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b700026), lymphoma\u2010related death (SOS; HR 13\u00b76; 95% CI [2\u00b79\u201365]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b700014) and risk of transformation (transformation\u2010free survival (TFS); HR 82\u00b77; 95% CI [14\u00b78\u2013463\u00b74]; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001). In conclusion, <jats:italic>MYC<\/jats:italic>\u2010EC has no prognostic impact in FL but <jats:italic>MYC<\/jats:italic>\u2010R FL tended to be associated with an increased risk of transformation and poorer outcome.<\/jats:p>","DOI":"10.1111\/bjh.17550","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T01:53:56Z","timestamp":1624326836000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Adverse outcome in follicular lymphoma is associated with <i>MYC<\/i> rearrangements but not <i>MYC<\/i> extra copies"],"prefix":"10.1111","volume":"194","author":[{"given":"Lucile","family":"Bussot","sequence":"first","affiliation":[{"name":"Department of Hematology Grenoble\u2010Alpes University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Cellular Hematology department Grenoble\u2010Alpes university hospital Grenoble France"},{"name":"Grenoble\u2010Alpes university Grenoble France"},{"name":"Institute for Advanced Biosciences (INSERM U1209 \/ CNRS UMR5309 \/ UGA) Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Cristante","sequence":"additional","affiliation":[{"name":"Grenoble\u2010Alpes university Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Grange","sequence":"additional","affiliation":[{"name":"Cytogenetic and molecular biology department Lyon\u2010Sud university hospital Hospices Civils de Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Tesson","sequence":"additional","affiliation":[{"name":"Institut Carnot CALYM Pierre\u2010B\u00e9nite 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Lyon Lyon\u2010Sud Hospital Pierre Benite France"},{"name":"Claude Bernard Lyon\u20101 University Lyon University Lyon France"},{"name":"Cancer Research Center of Lyon UMR INSERM 1052 CNRS 5286, Team \u00abClinical and experimental models of lymphomagenesis\u00bb Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Emadali","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences (INSERM U1209 \/ CNRS UMR5309 \/ UGA) Grenoble Alpes University Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Valmary\u2010Degano","sequence":"additional","affiliation":[{"name":"Grenoble\u2010Alpes university Grenoble France"},{"name":"Department of pathology Grenoble Alpes University Hospital Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Huet","sequence":"additional","affiliation":[{"name":"Claude Bernard Lyon\u20101 University Lyon 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