{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T16:44:45Z","timestamp":1775061885300,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients receiving targeted cancer treatments such as tyrosine kinase inhibitors (TKIs) have been classified in the clinically extremely vulnerable group to develop severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102), including patients with chronic myeloid leukaemia (CML) taking TKIs. In addition, concerns that immunocompromised individuals with solid and haematological malignancies may not mount an adequate immune response to a single dose of SARS\u2010CoV\u20102 BNT162b2 (Pfizer\u2010BioNTech) vaccine have been raised. In the present study, we evaluated humoral and cellular immune responses after a first injection of BNT162b2 vaccine in 16 patients with CML. Seroconversion and cellular immune response before and after vaccination were assessed. By day 21 after vaccination, anti\u2010Spike immunoglobulin G was detected in 14\/16 (87\u00b75%) of the patients with CML and all developed a neutralising antibody response [serum dilution that inhibits 50% infection (ID<jats:sub>50<\/jats:sub>) &gt;50], including medium (ID<jats:sub>50<\/jats:sub> of 200\u2013500) or high (ID<jats:sub>50<\/jats:sub> of 501\u20132000) neutralising antibodies titres in nine of the 16 (56\u00b725%) patients. T\u2010cell response was seen in 14\/15 (93\u00b73%) evaluable patients, with polyfunctional responses seen in 12\/15 (80%) patients (polyfunctional CD4<jats:sup>+<\/jats:sup> response nine of 15, polyfunctional CD8<jats:sup>+<\/jats:sup> T\u2010cell response nine of 15). These data demonstrate the immunogenicity of a single dose of SARS\u2010CoV\u20102 BNT162b2 vaccine in most patients with CML, with both neutralising antibodies and polyfunctional T\u2010cell responses seen in contrast to patients with solid tumour or lymphoid haematological malignancies.<\/jats:p>","DOI":"10.1111\/bjh.17568","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T13:21:15Z","timestamp":1622812875000},"page":"999-1006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Single dose of BNT162b2 mRNA vaccine against severe acute respiratory syndrome coronavirus\u20102 (SARS\u2010CoV\u20102) induces neutralising antibody and polyfunctional T\u2010cell responses in patients with chronic myeloid leukaemia"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5704-466X","authenticated-orcid":false,"given":"Patrick","family":"Harrington","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London UK"},{"name":"School of Cancer and Pharmaceutical Science King\u2019s College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie J.","family":"Doores","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases School of Immunology and Microbial Sciences King\u2019s College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3578-0102","authenticated-orcid":false,"given":"Deepti","family":"Radia","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Guy\u2019s and St Thomas\u2019 NHS Foundation Trust London 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