{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:31:57Z","timestamp":1754598717061,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Splenic marginal zone lymphoma (SMZL) is a rare low\u2010grade B\u2010cell lymphoma where associations with viral hepatitis and autoimmune and inflammatory diseases (AID) have been indicated. We aimed at assessing the prevalence of viral hepatitis and AID at SMZL diagnosis and outcome by treatment in a Swedish population\u2010based study. A total of 277 SMZL patients registered in the Swedish Lymphoma Register in 2007\u20132017 were included. A history of viral hepatitis was reported in five (2%) patients and AID prior to SMZL in 72\/240 (30%) patients. Treatment was given up front for 207 (75%) patients. Splenectomy with or without systemic treatment was performed in 119 (57%) and was associated with statistically significantly better overall survival [hazard ratio, HR\u00a0=\u00a00\u00b747 (95% confidence interval, CI: 0\u00b723\u20130\u00b793), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703] and progression\u2010free survival (HR\u00a0=\u00a00\u00b755, 95% CI: 0\u00b735\u20130\u00b786, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7008) compared to non\u2010splenectomised patients in multivariable analyses. The up\u2010front splenectomised group was younger and generally had a lower Ann Arbor stage, but also more frequently B symptoms and high lactate dehydrogenase than the non\u2010splenectomised group. Viral hepatitis and AID history did not affect SMZL outcome. We report high incidence of AIDs and low incidence of viral hepatitis in this population\u2010based study of SMZL. Splenectomy up front was associated with a favourable outcome.<\/jats:p>","DOI":"10.1111\/bjh.17577","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T20:26:18Z","timestamp":1623356778000},"page":"568-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Superior outcome for splenectomised patients in a population\u2010based study of splenic marginal zone lymphoma in Sweden"],"prefix":"10.1111","volume":"194","author":[{"given":"Andreea","family":"Sima","sequence":"first","affiliation":[{"name":"Clinical and Experimental Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0226-5681","authenticated-orcid":false,"given":"Peter","family":"Hollander","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Baecklund","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Rheumatology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology Department of Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[{"name":"Experimental and Clinical Oncology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-5252","authenticated-orcid":false,"given":"Rose\u2010Marie","family":"Amini","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Pathology Department of Immunology, Genetics and Pathology Uppsala University Uppsala University Hospital Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.371"},{"key":"e_1_2_8_3_1","first-page":"29","article-title":"Splenic marginal zone lymphoma: a review of the clinical presentation, pathology, molecular biology, and management","volume":"4","author":"Sena L","year":"2014","journal-title":"Blood Lymphat Cancer"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33117"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13320"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1841"},{"issue":"2","key":"e_1_2_8_7_1","first-page":"84","article-title":"Splenic marginal zone lymphoma in Turkey: association with hepatitis B instead of hepatitis C virus as an etiologic and possible prognostic factor \u2010 a multicenter cohort study","volume":"37","author":"Okay M","year":"2020","journal-title":"Turk J Haematol"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20137"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3230"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11893"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24287"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-07-2216"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjhh.2016.09.014"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0105-4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.07.006"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-11-624312"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0251"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2019.10.010"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10245332.2017.1279842"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1900-4"},{"key":"e_1_2_8_22_1","unstructured":"Swedishlymphoma. 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