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Some disease\u2010modifying and curative therapies have increased haemoglobin (Hb) levels to exceed 100\u2009g\/l, a threshold above which complications from red blood cell (RBC) transfusions have occurred, raising concern about whole\u2010blood viscosity\u2010related complications with these therapies. Here we discuss the rationale behind this limit, the effect of viscosity on blood flow and the applicability of this Hb threshold to therapies for SCD beyond RBC transfusions.<\/jats:p>","DOI":"10.1111\/bjh.17578","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:49:35Z","timestamp":1623804575000},"page":"518-522","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Time to rethink haemoglobin threshold guidelines in sickle cell disease"],"prefix":"10.1111","volume":"195","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1466","authenticated-orcid":false,"given":"Samir K.","family":"Ballas","sequence":"first","affiliation":[{"name":"Department of Medicine Cardeza Foundation for Hematologic Research Sidney Kimmel Medical College Thomas Jefferson University Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans A.","family":"Kuypers","sequence":"additional","affiliation":[{"name":"Children's Hospital Oakland Research Institute Oakland CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-7295","authenticated-orcid":false,"given":"Victor R.","family":"Gordeuk","sequence":"additional","affiliation":[{"name":"University of Illinois Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-7321","authenticated-orcid":false,"given":"Jane S.","family":"Hankins","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Ann &amp; Robert H. 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