{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T05:07:22Z","timestamp":1774156042401,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Familial thrombocytosis (FT) is a rare hereditary haematological disorder characterised by increased platelet count, usually caused by germ\u2010line mutations in thrombopoietin (<jats:italic>THPO<\/jats:italic>), myeloproliferative leukaemia virus oncogene (<jats:italic>MPL<\/jats:italic>) or Janus kinase 2 (<jats:italic>JAK2<\/jats:italic>) genes, and can be associated with increased risk of thrombosis. We aimed to determine the yield of diagnostic tests, assess treatment received and describe the clinical course of <jats:italic>MPL<\/jats:italic>\u2010associated FT. We retrospectively reviewed all paediatric and adult haematology patients diagnosed with <jats:italic>MPL<\/jats:italic>\u2010related FT, who were seen in our clinics from March 2013 to February 2021. Of 64 eligible patients, 26 (41%) were aged &lt;14\u00a0years, while the remaining 38 (59%) patients were adults. The median (interquartile range) age at diagnosis was 20\u00a0(33\u00b75)\u00a0years. In all, 26 tribes were represented in this cohort of 64 patients, out of which 31 (48%) patients belonged to two tribes. A total of 60 patients (94%) had thrombocytosis on blood count. Additional genetic tests, including myelodysplastic syndrome (<jats:italic>MDS<\/jats:italic>) gene panel, Philadelphia gene breakpoint cluster region\u2010Abelson (<jats:italic>BCR\u2010ABL<\/jats:italic>) and <jats:italic>JAK2<\/jats:italic>, were carried out for 52 patients and only one patient was positive for <jats:italic>JAK2<\/jats:italic> mutation. In all, 21 (33%) patients were prescribed aspirin and seven (11%) were prescribed hydroxyurea. Overall, 63 (98%) patients did not develop any thrombotic or haemorrhagic event. There was no significant association of <jats:italic>MPL<\/jats:italic>\u2010mutated FT with thrombosis or haemorrhage.<\/jats:p>","DOI":"10.1111\/bjh.17624","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T03:55:34Z","timestamp":1623815734000},"page":"893-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical course of myeloproliferative leukaemia virus oncogene <i>(<\/i><i>MPL<\/i>) mutation\u2010associated familial thrombocytosis: a review of 64 paediatric and adult patients"],"prefix":"10.1111","volume":"194","author":[{"given":"Talal","family":"Al\u2010Harbi","sequence":"first","affiliation":[{"name":"King Abdullah Specialized Children\u2019s Hospital Riyadh Saudi Arabia"},{"name":"King Abdullah International Medical Research Centre Riyadh Saudi Arabia"},{"name":"King Saud bin Abdulaziz University for Health Sciences Riyadh Saudi 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