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By employing next\u2010generation sequencing and multiplex ligation\u2010dependent probe amplification of tumour samples from 26 patients, we identified somatic alterations in paediatric PTCL including Epstein\u2013Barr virus (EBV)\u2010negative (EBV<jats:sup>\u2013<\/jats:sup>) and EBV\u2010positive (EBV<jats:sup>+<\/jats:sup>) patients. As recurrent mutational targets for PTCL, we identified several previously unreported genes, including <jats:italic>TNS1<\/jats:italic>, <jats:italic>ZFHX3<\/jats:italic>, <jats:italic>LRP2,<\/jats:italic> <jats:italic>NCOA2<\/jats:italic> and <jats:italic>HOXA1<\/jats:italic>, as well as genes previously reported in adult patients, e.g. <jats:italic>TET2<\/jats:italic>, <jats:italic>CDKN2A<\/jats:italic>, <jats:italic>STAT3<\/jats:italic> and <jats:italic>TP53<\/jats:italic>. However, for other reported mutations, <jats:italic>VAV1<\/jats:italic>\u2010related abnormalities were absent and mutations of <jats:italic>NRAS<\/jats:italic>, <jats:italic>GATA3<\/jats:italic> and <jats:italic>JAK3<\/jats:italic> showed a low frequency in our cohort. Concerning the association of EBV infection, two novel fusion genes: <jats:italic>STAG2\u2010AFF2<\/jats:italic> and <jats:italic>ITPR2\u2010FSTL4<\/jats:italic>, and deletion and alteration of <jats:italic>CDKN2A\/2B<\/jats:italic>, <jats:italic>LMO1<\/jats:italic> and <jats:italic>HOXA1<\/jats:italic> were identified in EBV<jats:sup>\u2013<\/jats:sup> PTCL, but not in EBV<jats:sup>+<\/jats:sup> PTCL. Conversely, alterations of <jats:italic>PCDHGA4<\/jats:italic>, <jats:italic>ADAR<\/jats:italic>, <jats:italic>CUL9<\/jats:italic> and <jats:italic>TP53<\/jats:italic> were identified only in EBV<jats:sup>+<\/jats:sup> PTCL. Our observations suggest a clear difference in the molecular<\/jats:p><jats:p>mechanism of onset between paediatric and adult PTCL and a difference in the characteristics of genetic alterations between EBV<jats:sup>\u2013<\/jats:sup> and EBV<jats:sup>+<\/jats:sup> paediatric PTCL.<\/jats:p>","DOI":"10.1111\/bjh.17639","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T05:57:18Z","timestamp":1626242238000},"page":"718-729","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characteristics of genetic alterations of peripheral T\u2010cell lymphoma in childhood including identification of novel fusion genes: the Japan Children\u2019s Cancer Group (JCCG)"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2838-4555","authenticated-orcid":false,"given":"Kentaro","family":"Ohki","sequence":"first","affiliation":[{"name":"Department of Pediatric 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