{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:39:46Z","timestamp":1782275986216,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Allogeneic haematopoietic stem cell transplantation (allo\u2010HSCT) is one of the curative treatment options for acute lymphoblastic leukaemia (ALL). However, the outcomes in patients transplanted without complete remission (non\u2010CR) have not yet been fully reported, and detailed analyses are required to identify subgroups in which optimal prognosis is expected and to optimize pre\u2010transplant therapeutic strategies. Hence, we performed a multicentred retrospective cohort study including a total of 663 adult ALL patients transplanted at non\u2010CR status; the median bone marrow (BM) blast counts at HSCT was 13\u00b72%, and 203 patients (30\u00b76%) were treated at primary induction failure status. The overall survival (OS) was 31\u00b71% at two years, and the multivariate analyses identified five prognostic risk factors, including older age (\u226550\u00a0years), increased BM blasts (\u226510%), poor performance status, high haematopoietic cell transplantation (HCT)\u2010comorbidity index, and relapsed disease status, among which BM blast was the most significantly related. A predictive scoring system composed of these risk factors clearly stratified OS (15\u00b76\u201359\u00b75% at two years). In conclusion, this is the first large\u2010scale study to analyze the correlation of patient characteristics with post\u2010transplant prognosis in ALL transplanted at non\u2010CR status. The importance of blast control before HSCT should be focused on for better patient prognosis.<\/jats:p>","DOI":"10.1111\/bjh.17646","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T04:05:36Z","timestamp":1624421136000},"page":"403-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Residual disease is a strong prognostic marker in patients with acute lymphoblastic leukaemia with chemotherapy\u2010refractory or relapsed disease prior to allogeneic stem cell transplantation"],"prefix":"10.1111","volume":"194","author":[{"given":"Momoko","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Graduate School of Medicine, Kyoto University Kyoto 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Hematology Japanese Red Cross Nagoya First Hospital Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatsugu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematology Kanagawa Cancer Center Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Sawa","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Anjo Kosei Hospital Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Hematology Hiroshima Red Cross Hospital &amp; Atomic\u2010bomb Survivors Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Hematology Jichi Medical University Saitama Medical Center Saitama 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