{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:15:52Z","timestamp":1788833752833,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100002491","name":"Bristol-Myers Squibb","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Dasatinib is a second\u2010generation BCR\u2010ABL1 tyrosine kinase inhibitor approved for patients with chronic myeloid leukaemia (CML). Dasatinib 100\u00a0mg per day is associated with an increased risk of pleural effusion (PlEff). We randomly evaluated whether therapeutic drug monitoring (TDM) may reduce dasatinib\u2010associated significant adverse events (AEs) by 12\u00a0months (primary endpoint). Eligible patients started dasatinib at 100\u00a0mg per day followed by dasatinib (C)min assessment. Patients considered overdosed [(C)min \u2265 3\u00a0nmol\/l) were randomised between a dose\u2010reduction strategy (TDM arm) and standard of care (control arm). Out of 287 evaluable patients, 80 patients were randomised. The primary endpoint was not met due to early haematological AEs occurring before effective dose reduction. However, a major reduction in the cumulative incidence of PlEff was observed in the TDM arm compared to the control arm (4% vs. 15%; 11% vs. 35% and 12% vs. 39% at one, two and three\u00a0years, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00\u00b70094)). Molecular responses were superimposable in all arms. Dasatinib TDM during treatment initiation was feasible and resulted in a significant reduction of the incidence of PlEff in the long run, without impairing molecular responses. (NCT01916785;\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                    ).\n                  <\/jats:p>","DOI":"10.1111\/bjh.17654","type":"journal-article","created":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T06:22:51Z","timestamp":1625120571000},"page":"393-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Dasatinib dose optimisation based on therapeutic drug monitoring reduces pleural effusion rates in chronic myeloid leukaemia patients"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-4494","authenticated-orcid":false,"given":"Philippe","family":"Rousselot","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Centre Hospitalier de Versailles Le Chesnay France"},{"name":"UMR1184 IDMIT Department Universit\u00e9 Paris\u2010Saclay Commissariat \u00e0 l'\u00e9nergie atomique et aux \u00e9nergies alternatives University of Versailles Saint\u2010Quentin\u2010en\u2010Yvelines Montigny\u2010Le\u2010Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigina","family":"Mollica","sequence":"additional","affiliation":[{"name":"Department of Hematology H\u00f4pital Maisonneuve\u2010Rosemont University of Montr\u00e9al Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"Guilhot","sequence":"additional","affiliation":[{"name":"Inserm CIC 1402 CHU de Poitiers Poitiers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Guerci","sequence":"additional","affiliation":[{"name":"Department of Hematology CHU Brabois Vandoeuvre Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck 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