{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:22:53Z","timestamp":1790306573128,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA021765"],"award-info":[{"award-number":["P30 CA021765"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Chimeric antigen receptor T\u2010cell (CAR T\u2010cell) therapy is associated with significant toxicities secondary to immune activation, including a rare but increasingly recognised severe toxicity resembling haemophagocytic lymphohistiocytosis (carHLH). We report the development of carHLH in 14\u00b78% of paediatric patients and young adults treated with CD19\u2010specific CAR T\u2010cell therapy with carHLH, occurring most commonly in those with high disease burden. The diagnosis and treatment of carHLH required a high index of suspicion and included multidrug immunomodulation with variable response to therapies. Compared to patients without carHLH, patients with carHLH had both reduced response to CAR T\u2010cell therapy (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00\u00b7018) and overall survival (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0&lt; 0\u00b70001).<\/jats:p>","DOI":"10.1111\/bjh.17662","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T10:51:33Z","timestamp":1626346293000},"page":"701-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["Hemophagocytic lymphohistiocytosis\u2010like toxicity (carHLH) after CD19\u2010specific CAR T\u2010cell therapy"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-6175","authenticated-orcid":false,"given":"Melissa R.","family":"Hines","sequence":"first","affiliation":[{"name":"Department of Pediatric Medicine Division of Critical Care St Jude Children\u2019s Research Hospital Memphis 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