{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T03:41:02Z","timestamp":1784086862589,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Intravenous fluid therapy (IV\u2010FT) is routinely used in the treatment of vaso\u2010occlusive crises (VOCs), as dehydration possibly promotes and sustains erythrocyte sickling. Patients with sickle cell disease (SCD) are at risk of developing diastolic dysfunction and fluid overload due to IV\u2010FT. However, data on the adverse effects of IV\u2010FT for VOC is sparse. We aimed to evaluate the incidence and risk factors of fluid overload due to IV\u2010FT in patients with SCD. Consecutive hospitalisations for VOC treated with IV\u2010FT between September 2016 and September 2018 were retrospectively analysed. The median (interquartile range) age was 25\u00b70\u00a0(18\u00b73\u201333\u00b78)\u00a0years and 65% had a severe genotype (HbSS\/HbS\u03b2<jats:sup>0<\/jats:sup>\u2010thal). Fluid overload occurred in 21% of 100 patients. Hospital stay was longer in patients with fluid overload (6\u00b70 vs. 4\u00b70 days, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7037). A positive history of fluid overload (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017), lactate dehydrogenase level (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011), and top\u2010up transfusion during admission (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7005) were independently associated with fluid overload occurrence. IV\u2010FT was not reduced in 86% of patients despite a previous history of fluid overload. Fluid overload is frequently encountered during IV\u2010FT for VOC. IV\u2010FT is often not adjusted despite a positive history of fluid overload or when top\u2010up transfusion is indicated, emphasising the need for more awareness of this complication and a personalised approach.<\/jats:p>","DOI":"10.1111\/bjh.17696","type":"journal-article","created":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T11:48:50Z","timestamp":1626349730000},"page":"899-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Fluid overload due to intravenous fluid therapy for vaso\u2010occlusive crisis in sickle cell disease: incidence and risk factors"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7534-5084","authenticated-orcid":false,"given":"Aafke E.","family":"Gaartman","sequence":"first","affiliation":[{"name":"Department of Hematology Amsterdam UMC Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajab 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