{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:04Z","timestamp":1790673904162,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The role of minimal residual disease (MRD) in splenic marginal zone lymphoma (SMZL) has not been well studied. We prospectively designed a study to evaluate undetectable MRD (uMRD) by multiparameter flow cytometry as a prognostic factor. Residual disease level of &lt;0\u00b701% was defined as uMRD. A total of 71 newly diagnosed patients with bone marrow involvement were enrolled and all received rituximab\u2010based therapy. The overall response rate (ORR) was 98\u00b75% (70\/71), with a complete remission (CR) rate of 54\u00b79% (39\/71). There were a total of 295 MRD detections in bone marrow and 77\u00b74% patients (55\/71) had uMRD. The 5\u2010year progression\u2010free survival (PFS) [(74\u00b78\u00a0\u00b1\u00a06\u00b75)% vs. (31\u00b74\u00a0\u00b1\u00a012\u00b76)%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001] and 5\u2010year overall survival (OS) [(87\u00b72\u00a0\u00b1\u00a05\u00b76)% vs. (68\u00b79\u00a0\u00b1\u00a013\u00b74)%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7035] were significantly higher in uMRD patients than in MRD\u2010positive patients. The 5\u2010year PFS in partial remission (PR) patients with positive MRD was significantly poorer than that of PR patients with uMRD [(21\u00b71\u00a0\u00b1\u00a012\u00b79)% vs. (83\u00b73\u00a0\u00b1\u00a08\u00b78)%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005]. Multivariate prognostic analysis revealed that uMRD was an independent good prognostic factor for PFS (hazard ratio 0\u00b7162, 95% confidence interval 0\u00b7041\u20130\u00b7635; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009). All these results highlight uMRD as an independent prognostic factor in patients with SMZL, especially for patients who only achieve PR.<\/jats:p>","DOI":"10.1111\/bjh.17703","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T10:42:30Z","timestamp":1627641750000},"page":"862-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Undetectable minimal residual disease is an independent prognostic factor in splenic marginal zone lymphoma"],"prefix":"10.1111","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-7615","authenticated-orcid":false,"given":"Rui","family":"Lyu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Disease Hospital National Clinical Research Center for Hematological Disorders Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 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National Clinical Research Center for Hematological Disorders Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Disease Hospital National Clinical Research Center for Hematological Disorders Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology Institute of Hematology and Blood Disease Hospital National Clinical Research Center for Hematological Disorders Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 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